Intestinal Colonization and Nosocomial Spread of <I>Clostridium difficile</I> in Pediatric Cancer Patients Under Long-term Hospitalization

• MURABATA Mayumi

  Aichi Medical University College of Nursing Nagoya City University Graduate School of Nursing

• KATO Haru

  Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases

• YANO Hisako

  Nagoya City University Graduate School of Nursing

• OGURA Masamichi

  Nagoya City University Graduate School of Nursing

• SHIBAYAMA Junko

  Nagoya City University Hospital, Department of Central Clinical Laboratory

• WAKIMOTO Yukio

  Nagoya City University Hospital, Department of Central Clinical Laboratory

• ARAKAWA Yoshichika

  Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases

• MIZOKAMI Masashi

  Nagoya City University Hospital, Department of Central Clinical Laboratory

Bibliographic Information

Other Title

• 長期入院がん患児における <I>Clostridium difficile</I> 消化管保有と院内伝播に関する検討
• 長期入院がん患児におけるClostridium difficile消化管保有と院内伝播に関する検討
• チョウキ ニュウイン ガン カンジ ニ オケル Clostridium difficile ショウカカン ホユウ ト インナイ デンパ ニ カンスル ケントウ
• Intestinal Colonization and Nosocomial Spread of Clostridium difficile in Pediatric Cancer Patients Under Long-term Hospitalization

Abstract

Clostridium difficile is a major causative agent of antimicrobial-associated diarrhea, and the leading cause of nosocomial diarrhea. We clarified intestinal colonization and nosocomial spread of C. difficile in pediatric cancer patients undergoing antineoplastic therapy during long-term hospitalization. Subjects were 10 chil-dren with pediatric malignant diseases admitted from November 2005 to December 2006, aged 5 to 15 years, who received antineoplastic agents. Stool specimens were examined at hospitalization, after each course of treatment with antineoplastic chemotherapy, and when symptoms such as diarrhea or fever occurred.<BR>While C. difficile was detected from stool specimens of 8 of 10 children during their hospital stay, 6 of these 8 children were negative for C. difficile on the day of their admission. These results demonstrate that the use of antimicrobial agents and antineoplastic agents lead to overgrowth of C. difficile in intestinal tract of pediatric cancer patients.<BR>Five of the 8 children carried toxin A-positive, toxin B-positive C. difficle and 2 were diagnosed with C.difficile-associated diarrhea (CDAD). This demonstrates that CDAD is not a rare infection in pediatric cancer-patients. Nine C. difficile isolates from 8 children were analyzed by PCR ribotyping. Two isolates from 2 chil-dren were typed into the same type banding patterns of the remaining 7 isolates from 6 children were unique.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 82 (5), 419-426, 2008

  The Japanese Association for Infectious Diseases

Keywords

• <I>Clostridium diffici/e</I>-associated diarrhea (CDAD)
• cancer
• child
• nosocomial infection

Details

• CRID: 1390282680027787264
• NII Article ID: 10024802926
• NII Article ID: 130004331454
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.82.419
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 9661146
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9661146
• Web Site: https://search.jamas.or.jp/link/ui/2008372338
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed