水中熱基板法による炭酸置換型アパタイト皮膜ならびに炭酸置換型アパタイト／炭酸カルシウム複合皮膜の作製と骨伝導性評価

• 黒田 健介

  名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野

• 森山 幹子

  名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野

• 市野 良一

  名古屋大学エコトピア科学研究所

• 興戸 正純

  名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野

• 関 あずさ

  ハムリー株式会社

書誌事項

タイトル別名

• Formation and in Vivo Evaluation of Carbonate Apatite and Carbonate Apatite/CaCO3 Composite Films Using the Thermal Substrate Method in Aqueous Solution
• スイチュウ ネツ キバンホウ ニ ヨル タンサン チカンガタ アパタイト ヒマク ナラビニ タンサン チカンガタ アパタイト タンサン カルシウム フクゴウ ヒマク ノ サクセイ ト コツ デンドウセイ ヒョウカ

抄録

  We have studied the formation and carried out an in vivo evaluation of carbonate apatite (CO₃-Ap) and CO₃-Ap/CaCO₃ composite coatings on titanium substrates using the thermal substrate method. The coatings were formed on commercial pure titanium rods (diameter=2 mm, length=5 mm) and plates (thickness=0.3 mm) by the thermal substrate method in an aqueous solution that contained Ca(H₂PO₄)₂, CaCl₂, and NaHCO₃. The coating experiments were conducted at 40-140°C and pH=8 for periods of 15 or 30 min. The coating temperature and NaHCO₃ of the solution had a significant influence on the surface morphology (net-like, plate-like, needle-like, or sphere-like), the phase (single phase of CO₃-Ap or binary phase of CO₃-Ap and CaCO₃), and the carbonate content in the precipitated films. A subsequent autoclave treatment also had an effect on the films. A coated rod was implanted in a 10 weeks old male rat's tibia with a non-coated titanium rod being used as a control. The constructs were retrieved after a period of 14 d postimplantation and examined for new bone formation and for tissue response in the cancellous and cortical bone parts, respectively. Single-phase sphere-like CO₃-Ap had high osteoconductivity in the cortical bone region, and this increased with increasing carbonate content in the films. However, the osteoconductivity of the CO₃-Ap/CaCO₃ composite coatings decreased with increasing total carbonate content.<br>

収録刊行物

• 日本金属学会誌

  日本金属学会誌 73 (5), 346-353, 2009

  公益社団法人 日本金属学会

キーワード

• carbonate apatite
• hydroxyapatite
• calcium carbonate
• hydro-coating
• surface morphology
• thermal substrate method
• <i>in vivo</i>

詳細情報

• CRID: 1390001206478644736
• NII論文ID: 10024818589
• NII書誌ID: AN00187860
• DOI: 10.2320/jinstmet.73.346
• COI: 1:CAS:528:DC%2BD1MXot1Wjsrs%3D
• ISSN: 18806880
• ISSN: 24337501
• ISSN: 00214876
• NDL書誌ID: 10297692
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10297692
• Web Site: https://www.jstage.jst.go.jp/article/jinstmet/73/5/73_5_346/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可