Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats
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- KOSE Hiroyuki
- Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School Present address: Department of Life Science, Division of Natural Sciences, International Christian University
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- SADO Yoshikazu
- Division of Immunology, Shigei Medical Research Institute
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- YAMADA Takahisa
- Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University
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- MATSUMOTO Kozo
- Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School
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Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely unknown. Here we performed a whole genome scan using a backcross (BC) F1 (WKY × DA) × WKY population, for which the DA rat is a nonsusceptible control strain. We found two significant QTLs on chromosomes 1 and 12, which were involved in elevated levels of proteinuria and kidney weight index, respectively. The relevance of these QTLs with the genetic factors involved in autoimmunity and renal disease is discussed.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 58 (2), 193-198, 2009
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205045249152
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- NII論文ID
- 10024838466
- 130000122135
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- HANDLE
- 10191/30608
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- NDL書誌ID
- 10206665
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可