レストレス・レッグズ症候群―まだ認知されていない小児の不機嫌・睡眠異常の原因―

  • 毛利 育子
    大阪大学大学院医学系研究科子どものこころの分子統御機構研究センター
  • 加藤 久美
    大阪大学大学院医学系研究科子どものこころの分子統御機構研究センター
  • 下野 九理子
    大阪大学大学院発達統合医学小児科
  • 立花 直子
    関西電力病院睡眠関連疾患センター
  • 大薗 恵一
    大阪大学大学院発達統合医学小児科
  • 谷池 雅子
    大阪大学大学院医学系研究科子どものこころの分子統御機構研究センター

書誌事項

タイトル別名
  • Restless Legs Syndrome -Possible Unrecognized Cause for Insomnia and Irritability in Children-
  • Possible Unrecognized Cause for Insomnia and Irritability in Children
  • まだ認知されていない小児の不機嫌・睡眠異常の原因

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抄録

Restless legs syndrome (RLS) has gradually been recognized as a cause for insomnia in adults, but there have been few reports about children with RLS in Japan. Here we described seven pediatric RLS patients. All of the parents of our patients had difficult times to make their children sleep due to irritability, restlessness, and demanding bedtime routines. All patients had asked their parents to rub their feet in bed, and it took more than half an hour to soothe them until they fell asleep. Their mothers had been exhausted from this night-time routine. However, they did not consider the routine abnormal, as it had been their habitual behavior since infancy. Some parents were too distressed or embarrassed to describe the symptoms of their child properly. Five patients had clear family history and none had obvious periodic leg movements during sleep. All patients showed low levels of ferritin and iron supplementation was effective in five cases. In the severest two cases, pramipexole, but not iron, was dramatically effective. Both patients started to show RLS symptoms in the early days of infancy, which may suggest more severe hereditary dopaminergic dysfunction. RLS does occur in childhood and pediatricians should bear it in mind as one of the differential diagnoses when seeing children who are irritated and/or having difficulty in initiating their sleep.

収録刊行物

  • 脳と発達

    脳と発達 40 (6), 473-477, 2008

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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