Dexamethasone Enhances Fertility and Preovulatory Serum Prolactin Levels in eCG/hCG Primed Immature Rats
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- ROCKWELL L. Christie
- Department of Anthropology, Temple University
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- KOOS Robert D.
- Department of Physiology, University of Maryland School of Medicine
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Glucocorticoids have heterogeneous effects on reproductive function. We used a gonadotropin-primed, immature rat model to study the influence of dexamethasone (1 mg/kg), given during the latter stages of follicular development, on litter size, the number of oocytes released, and pituitary hormone levels. Dexamethasone-treated females released a larger number of oocytes at ovulation and gave birth to larger litters indicating the oocytes were viable. Survival to weaning age was not affected but average weight at weaning was lower for pups born to DEX-treated females. Serum FSH and LH were assayed at 12, 24 and 48 h following eCG and did not differ between dexamethasone-treated and control animals, but prolactin showed a prolonged pattern of elevation in DEX-treated females. Prolactin, which normally exhibits an elevation on proestrous, may modulate follicular development. Dexamethasone enhances fertility and fecundity possible through an effect of prolactin on follicle development, or by other direct effects on the ovary. These results may improve our understanding of the usefulness of DEX in assisted reproductive therapies for women.<br>
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 55 (3), 247-251, 2009
公益社団法人 日本繁殖生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001206336128384
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- NII論文ID
- 10024942178
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- NII書誌ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可