Spontaneous Endometrial Hyperplasia in the Uteri of IL-2 Receptor Beta-Chain Transgenic Mice
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- KUSAKABE Ken
- Department of Laboratory Animal Science, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- KISO Yasuo
- Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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- HONDO Eiichi
- Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
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- TAKESHITA Ai
- Department of Laboratory Animal Science, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- KATO Keiko
- Department of Laboratory Animal Science, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- OKADA Toshiya
- Department of Laboratory Animal Science, Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
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- SHIBATA Masa-Aki
- Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College
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- OTSUKI Yoshinori
- Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College
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Abstract
We found frequent and spontaneous proliferation of glandular epithelium and dilated cysts in the uteri of interleukin-2 receptor (IL2R) β-chain transgenic (Tg2Rβ) mice. The aim of this study was to examine the involvement of IL2R β-chain in the pathogenesis of endometrial hyperplasia (EH). Mouse uteri and serum were collected from Tg2Rβ and normal littermates (NL), which were classified into three groups according to age. The incidence of EH increased in an age-dependent manner in both types of mice. However, in old age, Tg2Rβ mice showed more serious phenotypes of EH than NL. Immunohistochemical analysis revealed specific localization of IL2R β-chain in the glandular epithelial cells, with a correlation to the degree of EH, not only in the Tg2Rβ uteri but also in the NL uteri. Immunoreactions of CD3 and CD25 were detected in the uteri of Tg2Rβ but were weak in the uteri of NL, and CD25-positive cells were distributed in the endometrial stroma and myometrium in the Tg2Rβ mice. These findings suggest that the IL2R β-chain induces growth potential for glandular epithelial cells and an immune-privileged condition mediated by CD25+regulatory-T cells.<br>
Journal
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 55 (3), 273-277, 2009
The Society for Reproduction and Development
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Details 詳細情報について
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- CRID
- 1390282681312835456
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- NII Article ID
- 10024942352
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- NII Book ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL BIB ID
- 10257838
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed