Molecular Cloning and Characterization of Porcine Homeodomain Transcription Factor Msx1

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  • ISHIKAWA Akio
    Division of Life Science, Graduate School of Agriculture, Meiji University
  • KATO Takako
    Institute of Reproduction and Endocrinology, Meiji University
  • SUSA Takao
    Division of Life Science, Graduate School of Agriculture, Meiji University
  • SANO Akiko
    Division of Life Science, Graduate School of Agriculture, Meiji University
  • KATO Yukio
    Division of Life Science, Graduate School of Agriculture, Meiji University Department of Life Science, School of Agriculture, Meiji University Institute of Reproduction and Endocrinology, Meiji University

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We cloned a porcine ortholog of homeodomain transcription factor Msx1 from the porcine pituitary cDNA library. The amino acid sequence of Msx1 shows high conservation among mammalian species. RT-PCR for porcine fetal and postnatal pituitaries showed that Msx1 is already expressed at early fetal day 40, decreases to a low level before birth and then remarkably decreases after birth. On the other hand, Msx1 expression was observed in all pituitary-derived cell line tested, with most in a gonadotrope lineage LβT4. Transfection assay demonstrated that Msx1 markedly repressed the basal Cga and Fshb gene expression, while Lhb expression was affected slightly. Taken together, Msx1 may play a role in repressing gene expression in the fetal and postnatal periods.<br>

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