Dopamine as an immune-modulator between dendritic cells and T cells and the role of dopamine in the pathogenesis of Rheumatoid Arthritis

• NAKANO Kazuhisa

  The first dept. of Internal Medicine, University of Occupational & Environmental Health

• MATSUSHITA Sho

  Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University

• SAITO Kazuyoshi

  The first dept. of Internal Medicine, University of Occupational & Environmental Health

• YAMAOKA Kunihiro

  The first dept. of Internal Medicine, University of Occupational & Environmental Health

• TANAKA Yoshiya

  The first dept. of Internal Medicine, University of Occupational & Environmental Health

Bibliographic Information

Other Title

• 樹状細胞－Ｔ細胞間における免疫修飾物質としてのドパミンの機能と関節リウマチの病態形成における役割

Abstract

  The nerve systems affect immune functions by releasing neurotransmitters through lymphocyte cell-surface receptors. A major neurotransmitter dopamine transmits signals via five different seven-transmembrane G protein-coupled receptors termed D1 to D5. There is wide evidence for a decreased risk of rheumatoid arthritis (RA) in patients with schizophrenia which is associated with the excessive stimulation of D2-like receptors by dopamine. However, the reason for the negative association between RA and schizophrenia is unknown.<br>   We previously demonstrated that dendritic cells (DCs) could synthesize and store dopamine, DC released dopamine to naive CD4 T cells upon DC-T cell interaction and affected helper T-cell differentiation. Because DCs have been proposed to play a pivotal role in the initiation and perpetuation of RA by presentation of arthritogenic antigens to T cells, we here assessed effects and functions of dopamine on immune cells during the pathogenesis of RA.<br>   In this paper, we overview the series of our research findings, and present the possibility of drug discovery which target at dopamine receptors.<br>

Journal

• Japanese Journal of Clinical Immunology

  Japanese Journal of Clinical Immunology 32 (1), 1-6, 2009

  The Japan Society for Clinical Immunology

Keywords

• dendritic cell
• T cell
• dopamine
• IL-17
• Rheumatoid Arthritis

Details

• CRID: 1390282679626989440
• NII Article ID: 10024961683
• NII Book ID: AN00357971
• DOI: 10.2177/jsci.32.1
• ISSN: 13497413
• ISSN: 09114300
• Web Site: http://www.jstage.jst.go.jp/article/jsci/32/1/32_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009188726
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed