遅発性筋痛モデルを使った筋性疼痛の末梢機構へのアプローチ

• 水村 和枝

書誌事項

タイトル別名

• <b>Approach to the peripheral mechanism of muscular pain using a model of delayed onset muscle soreness </b>

抄録

   Muscle pain is quite common, but its mechanism is not well understood. For analyzing peripheral mechanism of muscle pain, importance of non-invasive method evaluating pressure pain threshold (mechanical withdrawal threshold in animals) was discussed. For experimental model analyzing muscle pain mechanism, delayed onset muscle soreness model was developed by applying lengthening contraction (LC) to rats, and results obtained in this model was introduced. Existence of mechanical hyperalgesia in this model was demonstrated by measuring mechanical withdrawal threshold by Randall-Selitto apparatus equipped with a large probe with tip diameter of 2.6 mm and by examining c-Fos expression in the superficial dorsal horn. Increase in mechanical sensitivity (decrease in threshold and increase in response magnitude) of muscle C-fiber nociceptors was demonstrated by single nerve recording in vitro in the muscle which were hyperalgesic 2 days after LC, and this change is considered to be the peripheral mechanism for mechanical hyperalgesia after exercise. Absence of muscle damage and inflammation, existence of taut band and referred pain by compressing the taut band in this model suggest that this model will be suitable and useful for the study of neural mechanism of clinically important muscle pain conditions.

収録刊行物

• PAIN RESEARCH

  PAIN RESEARCH 23 (4), 177-183, 2008

  日本疼痛学会

キーワード

• Muscular pain
• Exercise
• Delayed onset muscle soreness
• Taut band
• Mechanical hyperalgesia

詳細情報

• CRID: 1390282679344181376
• NII論文ID: 10024965091
• NII書誌ID: AN10195934
• DOI: 10.11154/pain.23.177
• ISSN: 21874697
• ISSN: 09158588
• Web Site: https://www.jstage.jst.go.jp/article/pain/23/4/23_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009023934
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可