Tissue Doppler Echocardiography for Predicting Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

• Masugata Hisashi

  Department of Integrated Medicine, Kagawa University

• Senda Shoichi

  Department of Integrated Medicine, Kagawa University

• Goda Fuminori

  Department of Integrated Medicine, Kagawa University

• Yamagami Ayumu

  Department of Integrated Medicine, Kagawa University

• Okuyama Hiroyuki

  Department of Integrated Medicine, Kagawa University

• Kohno Takeaki

  Department of Integrated Medicine, Kagawa University

• Hosomi Naohisa

  Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University

• Yukiiri Kazushi

  Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University

• Noma Takahisa

  Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University

• Kiyomoto Hideyasu

  Department of Integrated Medicine, Kagawa University

• Murao Koji

  Division of Endocrinology and Metabolism, Kagawa University

• Nishiyama Akira

  Department of Pharmacology, Kagawa University

• Kohno Masakazu

  Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University

Abstract

It has been reported that left ventricular (LV) diastolic functional parameters assessed by conventional Doppler echocardiography, which measures blood flow velocities in cardiac cavity, correlate with arterial stiffness assessed by the cardio-ankle vascular index (CAVI) and are markers for increased risk of cardiovascular events. Recently, tissue Doppler echocardiography, which measures velocities of regional cardiac wall, has been widely used for assessment of LV diastolic function because of more accuracy than conventional Doppler echocardiography. However, there are no data regarding the ability of tissue Doppler echocardiography for predicting increased arterial stiffness. We investigated the correlation of LV diastolic functional parameters from tissue Doppler echocardiography to CAVI in order to clarify the ability of tissue Doppler echocardiography for predicting increased arterial stiffness in patients with cardiovascular risk factors. Enrolled in the study were 70 patients (69 ± 8 years) who had no overt heart disease, but had at least one of hypertension, diabetes, and dyslipidemia. The peak early diastolic mitral annular velocity (E') was measured as an index of LV diastolic function using tissue Doppler echocardiography. The E' was correlated with CAVI (r = −0.518, p < 0.001). The optimal cut-off point for the detection of abnormal CAVI (≥ 8.81) was 5.6 cm/s for E' (sensitivity 71%, specificity 71%). The decrease in E' correlated with both LV diastolic dysfunction and increased arterial stiffness. Therefore, the LV diastolic dysfunction assessed by tissue Doppler echocardiography may be useful for predicting increased arterial stiffness and cardiovascular events in the patients with risk factors.

Journal

• The Tohoku Journal of Experimental Medicine

  The Tohoku Journal of Experimental Medicine 217 (2), 139-146, 2009

  Tohoku University Medical Press

Keywords

• echocardiography
• left ventricular diastolic function
• cardiovascular risk factor
• arterial stiffness

Details

• CRID: 1390282679216374400
• NII Article ID: 10025105006
• NII Book ID: AA00863920
• DOI: 10.1620/tjem.217.139
• COI: 1:STN:280:DC%2BD1M7js1Snsw%3D%3D
• ISSN: 13493329
• ISSN: 00408727
• PubMed: 19212107
• Web Site: http://www.jstage.jst.go.jp/article/tjem/217/2/217_2_139/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009187510
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed