Role of Prostaglandin D2 and Its Receptors in the Pathophysiology of Asthma
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- Oguma Tsuyoshi
- Division of Pulmonary Medicine, Department of Medicine Shinanomachi Research Park, Keio University School of Medicine
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- Asano Koichiro
- Division of Pulmonary Medicine, Department of Medicine Shinanomachi Research Park, Keio University School of Medicine
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- Ishizaka Akitoshi
- Division of Pulmonary Medicine, Department of Medicine Shinanomachi Research Park, Keio University School of Medicine
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Abstract
Prostaglandin D2 (PGD2) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the identification of DP (DP1, PTGDR) and CRTH2 (DP2), two PGD2-specific transmembrane receptors with different distribution and intracellular signaling. Pharmacological tools, such as receptor-specific agonists and antagonists, and genetically-engineered mice, which lack either DP or CRTH2, have helped understand the complex effects of PGD2 in allergic inflammation of the airways. Furthermore, genetic association studies have shown a positive linkage of the genetic polymorphisms in DP and CRTH2, with asthma phenotypes from specific ethnic backgrounds, further highlighting the importance of PGD2 and its receptors in the pathophysiology of asthma.<br>
Journal
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- Allergology International
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Allergology International 57 (4), 307-312, 2008
Japanese Society of Allergology
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Details 詳細情報について
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- CRID
- 1390001204633866112
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- NII Article ID
- 10025108291
- 130004476990
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- NII Book ID
- AA11091750
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- COI
- 1:CAS:528:DC%2BD1MXnsFSisg%3D%3D
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- ISSN
- 14401592
- 13238930
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- PubMed
- 18946232
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed