Expression of p53-Regulated Genes in Cultured Mammalian Cells After Exposure to A Space Environment

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  • Ohnishi Takeo
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
  • Takahashi Akihisa
    Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
  • Suzuki Hiromi
    Japan Space Forum, 2-2-1 Ohtemachi, Chiyoda-ku, Tokyo 104-0004, Japan
  • Omori Katsunori
    Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan
  • Shimazu Toru
    Japan Space Forum, 2-2-1 Ohtemachi, Chiyoda-ku, Tokyo 104-0004, Japan
  • Ishioka Noriaki
    Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan

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Abstract

The space environment contains two major biologically significant influences; space radiation and microgravity. The tumor suppressor gene product p53 is generally thought to contribute to the genetic stability of cells with DNA damage through the activity of p53 initiated signal transduction pathways. We propose to investigate the expression of p53-regulated genes in cultured mammalian cells after exposure to a space environment. We expect that the data from this proposal will be useful for designing physiological protection against the serious effects of space radiation during long-term stays in space.

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