Enzyme-Release Capillary as a Facile Enzymatic Biosensing Part for a Capillary-Assembled Microchip

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  • HENARES Terence G.
    Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University
  • MAEKAWA Eiji
    Graduate School of Material Science, University of Hyogo
  • OKUBO Fumito
    Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University
  • MIZUTANI Fumio
    Graduate School of Material Science, University of Hyogo
  • YAO Toshio
    Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University
  • SEKIZAWA Ryuichi
    Metaboscreen Co. Ltd.
  • HISAMOTO Hideaki
    Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University

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Abstract

A simple capillary enzymatic biosensor was developed. This was prepared by simply coating a dissolvable membrane containing enzyme/s on the inner wall of a square glass capillary. An easy measurement was carried out by capillary force sample introduction with concurrent enzyme release and a reaction with a certain substrate. Enzyme-release capillary (ERC) biosensors showed long-term storage stability of at least two weeks for a β-galactoside derivative and glucose. Moreover, this could be integrated on a capillary-assembled microchip (CAs-CHIP) to broaden its multiple analyte sensing potential for clinical diagnostic applications.

Journal

  • Analytical Sciences

    Analytical Sciences 25 (8), 1025-1028, 2009

    The Japan Society for Analytical Chemistry

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