Impact of Unnatural Nucleosides on the Control of Microbial Growth

• HATANO AKIHIKO

  Department of Materials and Life Science, Shizuoka Institute of Science and Technology Department of Chemistry, Shibaura Institute of Technology

• NISHIMURA MAKOTO

  R & D Center, Permachem Asia, Ltd.

• SOUTA IKUO

  Department of Materials and Life Science, Shizuoka Institute of Science and Technology

抄録

This research investigated the antimicrobial activities of unnatural nucleosides. We tested the MIC and MBC of 17 synthetic nucleoside analogues against 10 microbial strains. These nucleoside analogues were classified into four groups according to their structural characteristics. Inhibition was observed with compounds 1-1, 3-1, and 4-3. In particular, 5'-deoxythymidine (3-1) was most effective at 50μg/mL against Bacillus subtilis and Staphylococcus aureus. This analogue has had the hydroxyl group at the 5' position replaced with a hydrogen atom. All compounds had weak effects against various species of mold. The MBC of 5'-deoxythymidine was 50μg/mL in 0.5 h against S. aureus. These results showed that 5'-deoxythymidine had the most effective antimicrobial activity of the 17 different unnatural nucleosides. The inhibitory effect of 3-1 suggests that it may be useful as an antibacterial agent in medical situations.

収録刊行物

• Ｂｉｏｃｏｎｔｒｏｌ　Ｓｃｉｅｎｃｅ

  Ｂｉｏｃｏｎｔｒｏｌ　Ｓｃｉｅｎｃｅ 14 (2), 55-60, 2009

  日本防菌防黴学会

キーワード

• Unnatural nucleoside
• Chemical structure
• MIC
• MBC

詳細情報

• CRID: 1390001204464066816
• NII論文ID: 10025217587
• NII書誌ID: AA11169621
• DOI: 10.4265/bio.14.55
• COI: 1:CAS:528:DC%2BD1MXoslaisrY%3D
• ISSN: 18840205
• ISSN: 13424815
• PubMed: 19579655
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可