セレンタンパク質の機能と生合成

• 江崎 信芳

  京都大学化学研究所

• 三原 久明

  京都大学化学研究所

書誌事項

タイトル別名

• Function and biosynthesis of selenoproteins
• セレンタンパクシツ ノ キノウ ト セイゴウセイ

抄録

Selenium, an essential trace element for humans, presents as a selenocysteine residue in selenoproteins, such as glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Selenocysteine is co-translationally incorporated into selenoproteins at an in-frame UGA codon, which usually serves as a stop codon, within the coding region of the mRNA and therefore is designated as the 21st amino acid in the genetic code. The translation of selenocysteine codon in mRNA during selenoprotein biosynthesis requires selenocysteyl (Sec)-tRNA^Sec. In general, aminoacyl-tRNA is synthesized from an amino acid and the corresponding tRNA isoacceptor in an ATP-dependent reaction catalyzed by an aminoacyl-tRNA synthetase. However, Sec-tRNA^Sec, unlike cognate aminoacyl-tRNA, is synthesized by an indirect tRNA-dependent amino acid formation mechanism. In this article, functions of several selenoproteins and enzymes involved in the biosynthetic pathway of selenoproteins are reviewed. In addition, the reaction mechanism of a selenium-specific enzyme, selenocysteine lyase, is discussed.

収録刊行物

• Biomedical Research on Trace Elements

  Biomedical Research on Trace Elements 19 (4), 308-316, 2008

  日本微量元素学会

キーワード

• selenoprotein
• biosynthesis
• function
• biochemistry
• selenium

詳細情報

• CRID: 1390001204366718336
• NII論文ID: 130004456874
• NII論文ID: 10025379915
• NII書誌ID: AN10423256
• DOI: 10.11299/brte.19.308
• ISSN: 18801404
• ISSN: 0916717X
• NDL書誌ID: 10165238
• Web Site: http://id.ndl.go.jp/bib/10165238
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10165238
• Web Site: https://search.jamas.or.jp/link/ui/2009176433
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可