Olfactory Nerve Imaging with SPECT/CT in Rats

• Shiga Hideaki

  Department of Otorhinolaryngology, Head and Neck Surgery, Kanazawa Medical University

• Washiyama Kohshin

  Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University

• Ogawa Kazuma

  Department of Clinical and Analytical Sciences, School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

• Yamaguchi Hiroshi

  Division of Animal Imaging, Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine

• Magata Yasuhiro

  Division of Animal Imaging, Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine Laboratory of Genome Biophotonics, Photon Medical Research Center, Hamamatsu University School of Medicine

• Amano Ryohei

  Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University

• Furukawa Mitsuru

  Kanazawa University

• Miwa Takaki

  Department of Otorhinolaryngology, Head and Neck Surgery, Kanazawa Medical University

Bibliographic Information

Other Title

• SPECT/CTによるラット嗅神経の画像評価

Abstract

Objective: To image the olfactory nerve in vivo using single-photon emission computed tomography (SPECT) and X-ray computed tomography (CT) after nasal thallium-201 (²⁰¹Tl) administration to rats.<br>Methods: Three 8-week-old female Wistar rats (Japan SLC, Shizuoka, Japan) used in this study were assessed under anesthesia (intraperitoneal administration of pentobarbital sodium; 0.05 mg/g body weight) for ²⁰¹Tl transport to the olfactory bulb 8h after nasal administration of ²⁰¹TlCl solution (50μl, 74 MBq/ml, Nihon Medi-Physics, Tokyo, Japan) using SPECT/CT (Flex X-SPECT, Gamma Medica-Ideas, USA). The heads of rats were assessed for autoradiography to confirm ²⁰¹Tl transport to the olfactory bulb after SPECT/CT.<br>Results: ²⁰¹Tl transport to the olfactory bulb was shown using SPECT/CT 8h after nasal administration of ²⁰¹Tl. Coronal section imaging especially indicated ²⁰¹Tl transport from the nasal cavity to the olfactory bulb. ²⁰¹Tl transport to the olfactory bulb was confirmed by autoradiography.<br>Conclusion: SPECT/CT showing ²⁰¹Tl transport to the olfactory bulb may be useful in visually assessing the olfactory nerve in vivo.

Journal

• Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology)

  Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 48 (2), 138-141, 2009

  Japan Rhinologic Society

Keywords

• olfactory nerve
• SPECT/CT
• thallium
• molecular imaging
• nasal administration
• coronal section

Details

• CRID: 1390001204736743936
• NII Article ID: 10025380412
• NII Article ID: 130004545999
• NII Book ID: AN00062865
• DOI: 10.7248/jjrhi.48.138
• ISSN: 18837077
• ISSN: 09109153
• Web Site: https://search.jamas.or.jp/link/ui/2009346351
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed