Revisiting Sensitization Mechanisms in Cancer Thermochemotherapy : Does the Production of Radicals Hold the Key to Sensitization ?

• MATSUMOTO HIDEKI

  Division of Oncology, Biomedical Imaging Research Center, University of Fukui

Bibliographic Information

Other Title

• がん温熱化学療法の増感メカニズムへの再訪- ラジカル産生が増感の鍵を握るのか？ -

Abstract

The mechanism involved in the potentiation of cell killing and antitumor activity which result from combined treatments with hyperthermia and chemotherapeutic drugs is believed to be an increase in DNA damage caused by an increase in drug uptake. These events can be brought about by the disruption of membrane permeability by hyperthermia. It has recently been suggested that the contribution of reactive oxygen species (ROS) to the cytotoxic activity of anti-cancer drugs may be important in combined treatments utilizing hyperthermia and chemotherapeutic drugs. The present review examines the possibility that ROS, generated from chemotherapeutic drugs or by interactions between chemotherapeutic drugs and biomaterials or hyperthermia, may make a major contribution to the potentiation of cell killing and antitumor activity in thermochemotherapy.

Journal

• Thermal Medicine

  Thermal Medicine 24 (1), 13-25, 2008

  Japanese Society for Thermal Medicine

Keywords

• hyperthermia
• chemotherapeutic drugs
• reactive oxygen species (ROS)

Details

• CRID: 1390001205286914688
• NII Article ID: 10025539459
• NII Article ID: 10025539544
• NII Book ID: AN10084762
• DOI: 10.3191/thermalmed.24.13
• ISSN: 18823750
• ISSN: 18822576
• NDL BIB ID: 9448992
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9448992
• Web Site: https://www.jstage.jst.go.jp/article/thermalmed/24/1/24_1_13/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008231427
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed