Adipocyte-derived factors, adipokines gene regulation.

• IHARA Hayato

  Dept. Physiol., Hamamatsu Univ. Sch. Med.

Bibliographic Information

Other Title

• 脂肪細胞から分泌される生理活性物質アディポカイン遺伝子発現制御
• シボウ サイボウ カラ ブンピツ サレル セイリ カッセイ ブッシツ アディポカイン イデンシ ハツゲン セイギョ

Abstract

Obesity is a major public health problem among the industrial countries. The WHO estimates that over 300 million people are clinically obese. Obesity is associated with prothrombic and proinflammation states, hypertension, dyslipidemia, hyperglycemia, insulin resistance. These obesity-related abnormalities are commonly referred to as the metabolic syndrome. Recently, it was reported that adipocyte itself synthesizes and secrets a large variety of molecules called adipokine including leptin, adiponectin, resistin, TNF α , TGF β , and PAI-1 etc, which act both at local (autocrine/paracrine) and systemic (endocrine) levels. Excessive production and secretion of adipokines may cause the obesity-associated metabolic syndrome. In this review, we summarize our studies on gene regulations of plasminogen activator inhibitor-1 (PAI-1) by adipocyte-enriched transcription factor, PPAR γ  and that of resistin with treatment of resveratrol in adipocytes and obese mice.

Journal

• Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)

  Hikaku seiri seikagaku(Comparative Physiology and Biochemistry) 26 (2), 47-57, 2009

  THE JAPANESE SOCIETY FOR COMPARATIVE PHYSIOLOGY AND BIOCHEMISTRY

Keywords

• Obesity
• Metabolic syndrome
• Adipocyte
• Adipokine
• PAI-1
• Resistin
• Resveratrol

Details

• CRID: 1390282679646875776
• NII Article ID: 10025617430
• NII Book ID: AN10391932
• DOI: 10.3330/hikakuseiriseika.26.47
• COI: 1:CAS:528:DC%2BD1MXlvVansL4%3D
• ISSN: 18819346
• ISSN: 09163786
• NDL BIB ID: 10275632
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10275632
• Web Site: https://search.jamas.or.jp/link/ui/2009219678
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed