塗抹陽性肺結核における安静呼気エアゾル中の結核菌について

• 川田 博

  独立行政法人国立病院機構南横浜病院

• 山里 将也

  独立行政法人国立病院機構南横浜病院

• 篠沢 陽子

  独立行政法人国立病院機構南横浜病院

• 鈴木 喜久雄

  独立行政法人国立病院機構南横浜病院

• 大谷 すみれ

  独立行政法人国立病院機構南横浜病院

• 根本 逸夫

  独立行政法人国立病院機構南横浜病院

• 宮入 守

  独立行政法人国立病院機構南横浜病院

書誌事項

タイトル別名

• EXHALED BREATH-GENERATED AEROSOLS OF MYCOBACTERIUM TUBERCULOSIS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS DURING NORMAL BREATHING
• トマツ ヨウセイ ハイケッカク ニ オケル アンセイ コキ エアゾルチュウ ノ ケッカクキン ニ ツイテ

抄録

[Objective] It has been understood that coughgenerated aerosols act as an important vector for the spread of pulmonary tuberculosis. Humans commonly exhale aerosols during the normal respiration process that contain small droplets of the airway lining fluid. We aimed to determine whether aerosols exhaled by active pulmonary tuberculosis (AP-TB) patients may contain droplets with Mycobacterium tuberculosis (M-TB) during normal breathing.<BR>[Methods] Preliminarily, the colle ction efficiency of M-TB that was suspended in normal saline or distilled water was examined after subjecting the suspension to centrifugation at 3, 000 g for 20 minutes. Better collection efficiency was observed in case of M-TB suspended in distilled water than that suspended in normal saline after centrifugation. Therefore, we selected distilled water instead of normal saline to prepare the fluid that was bubbled with exhaled breath. AP-TB patients with smear positive pulmonary tuberculosis who were being treated with anti-TB drugs for less than 7 days or those before the initiation of therapy expired into a 50-ml tube containing 10 ml distilled water for 30 minutes. We also prepared an exhaled breath condensate by cooling exhaled air through the tubing apparatus.<BR>[Results] In case of 20 AP-TB patients, the distilled water bubbled with the exhaled breath were negative for M-TB on smear, culture, and PCR (polymerase chain reaction) detection methods. The exhaled breath condensates were also negative in 24 AP-TB patients.<BR>[Conclusio n] These results suggest that exhaled breathgenerated aerosols from AP-TB patients during normal breathing do not act as a vector for the spread of pulmonary tuberculosis.

収録刊行物

• 結核

  結核 83 (4), 387-391, 2008

  一般社団法人 日本結核病学会

キーワード

• 疾患の伝染
• 空気感染と微生物学
• 感染性
• 伝染性疾患の制御
• 肺結核

詳細情報

• CRID: 1390001204999414784
• NII論文ID: 10025688563
• NII書誌ID: AN00073442
• DOI: 10.11400/kekkaku1923.83.387
• ISSN: 18842410
• ISSN: 00229776
• NDL書誌ID: 9472863
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9472863
• Web Site: https://search.jamas.or.jp/link/ui/2008194870
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可