EFFECTS OF PROPHYLAXIS ON QuantiFERON TB-2G RESPONSES AMONG CHILDREN

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  • HIGUCHI Kazue
    Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA)
  • OKADA Kenji
    National Hospital Organization Fukuoka National Hospital
  • HARADA Nobuyuki
    Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA)
  • MORI Toru
    Leprosy Research Center, National Institute of Infectious Diseases

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Other Title
  • 小児における潜在性結核感染症治療のクォンティフェロンＴＢ‐２Ｇ応答に及ぼす影響
  • ショウニ ニ オケル センザイセイ ケッカク カンセンショウ チリョウ ノ クォンティフェロン TB 2G オウトウ ニ オヨボス エイキョウ

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Abstract

[Objective] To study the effect of treatment of latent tuberculosis infection (LTBI) on QuantiFERONRTB-2G (QFT-2G) test results.<BR>[Subjects an d methods] QFT-2G was used for a contact investigation in a junior high school and those positive or doubtful positive (TB Antigen-Nil response ≥ 0.1 and <0.35IU/ml) were indicated for treatment of LTBI with IN H. All subjects who completed treatment of LTBI were re-tested with QFT-2G approximately 1 month after completion of treatment and a subset were again re-tested 8 to 11 months after the completion of treatment. The levels of IFN- γ response in each QFT-2G test were compared.<BR>[Results] Initiall y, 43 subjects (28 Q1-, 11-2Gp ositive and 15 doubtful positive) were indicated treatment of LTBI, and 41 (95 %) completed 6-months treatment. These 41 subjects were re-tested with QFT-2G approximately 1 month after the completion of treatment. Among 28 pre-treatment positives, 19 remained positive, 6 became doubtful positive, and 3reverted to negative. Among 13 pre-treatment doubtful positives, 1 converted to positive, 5 remained doubtful positive, and 7 reverted to negative. The QFT-2G responses after the completion of treatment significantly declined compared with the pre-treatment level (geometric means; before treatment ESAT-6: 0.30 IU/ml, CFP-10: 0.09 IU/ml, after treatment ESAT-6: 0.18 IU/ml, CFP-10: 0.05 IU/ml, dependent t-test; ESAT-6: p= 0.020, CFP-10: p = 0.005). At 8 to 11 months after the completion of treatment, 30 randomly selected subjects received the third QFT-2G test. Among 19positives at the completion of treatment, 14 remained positive, 4 become doubtful positive, and 1 reverted to negative. Among 8 doubtful positives at completion of treatment, 4 converted to positive, 3 remained doubtful positive, and I reverted to negative. A further decline of QFT-2G responses was not observed. Three subjects negative at the completion of treatment were re-tested and remained negative at the third test.<BR>[Conclusion] Q FT-20 responses significantly decline d after the treatment of LTBI, despite the rate of reversion in QFT-2G being low. This low reversion rate suggests QFT-20 would not be useful as a marker to evaluate the success of treatment for LTBI. However, the finding that QFT-2G responses significantly decline after the treatment of LTBI suggests the possibility that this decline could be used as a marker of the susceptibility of the infective M. tuberculosis. strain to the prophylactic drug used. The outbreak investigation has been carried out for over two years, and none of 229 students who were TST positive, but QFT-2G negative and because of this result not indicated treatment of LTBI, have developed TB, suggesting that QFT-2G reflects TB infection more accurately than the TST, even in school children.

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