造血幹細胞由来線維芽細胞および筋線維芽細胞の同定とその臨床応用

• 海老原 康博

  東京大学医科学研究所付属病院小児細胞移植科

書誌事項

タイトル別名

• Identification and Clinical Application of Fibroblasts/Myofibroblasts Derived from Hematopoietic Stem Cells

抄録

Tissue fibrobiasts/myofibroblasts play a key role in growth factor secretion and extracellularmatrix protein production, and therefore regulate the inflammation responses in the processes of wound healing. Once the origin of tissue fibroblasts/myofibroblasts was thought to be local tissues themselves; recently, it was proved that the fibroblasts/myofibroblasts are derived from bone marrow. We have carried out studies of tissue reconstitution by transplanting clones derived from a single hematopoietic stem cell (HSC) expressing transgenic enhanced green fluorescent protein (EGFP). We found that there were EGFP⁺ fibroblasts/myofibroblasts in many organs and tissues which were derived from the HSC, excluding the possibility of cell fusion. Since fibroblasts/myofibroblasts are important in the pathological process and maintenance of steady state, it is of interest for the application of regenerative medicine to clarify the newly identified road from HSC to fibroblasts/myofibroblasts

収録刊行物

• 日本小児血液学会雑誌

  日本小児血液学会雑誌 22 (1), 1-6, 2008

  特定非営利活動法人　日本小児血液・がん学会

キーワード

• fibroblasts
• myofibroblasts
• hematopoietic stem cell
• mesenchymal stem cell
• enhanced green fluorescent protein

詳細情報

• CRID: 1390282679319671040
• NII論文ID: 130004345963
• NII論文ID: 10025700202
• NII書誌ID: AN10080852
• DOI: 10.11412/jjph1987.22.1
• ISSN: 18844723
• ISSN: 09138706
• Web Site: https://search.jamas.or.jp/link/ui/2008140151
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可