Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia

DOI Web Site PubMed 被引用文献6件 参考文献23件
  • Kitamura Yoshihisa
    Department of Neurobiology, Kyoto Pharmaceutical University 21st Century COE Program, Kyoto Pharmaceutical University
  • Yanagisawa Daijiro
    Department of Neurobiology, Kyoto Pharmaceutical University
  • Inden Masatoshi
    Department of Neurobiology, Kyoto Pharmaceutical University
  • Takata Kazuyuki
    Department of Neurobiology, Kyoto Pharmaceutical University
  • Tsuchiya Daiju
    Department of Neurobiology, Kyoto Pharmaceutical University
  • Kawasaki Toshiyuki
    Department of Neurobiology, Kyoto Pharmaceutical University
  • Taniguchi Takashi
    Department of Neurobiology, Kyoto Pharmaceutical University 21st Century COE Program, Kyoto Pharmaceutical University
  • Shimohama Shun
    Department of Neurology, Graduate School of Medicine, Kyoto University

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The function of microglia in the brain parenchyma is not fully understood. Occlusion of the middle cerebral artery (MCA) and reperfusion caused behavioral dysfunction with massive neuronal loss in the rat cerebral cortex and striatum. When exogenous microglia were microinjected into the intracerebroventricle (i.c.v.) during MCA occlusion, focal ischemia-induced behavioral dysfunction was significantly inhibited. At that time, many microglia migrated into the ischemic lesion, and microglia-derived neuron-like cells were barely detectable. These results suggest that exogenous microglia protect against focal ischemia-induced neurodegeneration and improve behavioral dysfunction.<br>

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