Chronic Nicotine Treatment Upregulates L-Type High Voltage-Gated Calcium Channels

• Katsura Masashi

  Department of Pharmacology, Kawasaki Medical University

• Ohkuma Seitaro

  Department of Pharmacology, Kawasaki Medical University

書誌事項

タイトル別名

• Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Chronic Nicotine Treatment Upregulates L-Type High Voltage-Gated Calcium Channels

抄録

Neurochemical mechanisms underlying drug dependence and withdrawal syndrome remain unclear. In this review, we discuss how chronic nicotine exposure to neurons affects expression of diazepam binding inhibitor (DBI), an endogenous anxiogenic neuropeptide supposed to be a common substance participating drug dependence, and function of L-type high voltage-gated Ca²⁺ channels (HVCCs). We also discuss the functional interaction between DBI and L-type HVCCs in nicotine dependence. Both DBI levels and [⁴⁵Ca²⁺] influx significantly increased in the brain from mice treated with nicotine for long term, which was further enhanced after abrupt cessation of nicotine and was abolished by nicotinic acetylcholine receptor (nAChR) antagonists. Similar responses of DBI expression and L-type HVCC function were observed in cerebral cortical neurons after sustained exposure to nicotine. In addition, increased DBI expression was inhibited by antagonists of nAChR and L-type HVCCs. Sustained exposure of neurons to nicotine significantly enhanced expression of α₁ and α₂/δ₁ subunits for L-type HVCCs and caused an increase in the B_max value of [³H]verapamil binding to the particulate fractions. Therefore, it is concluded that the alterations in DBI expression is mediated via increased influx of Ca²⁺ through upregulated L-type HVCCs and these neurochemical changes have a close relationship with development of nicotine dependence and/or its withdrawal syndrome.<br>

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 97 (3), 344-347, 2005

  公益社団法人 日本薬理学会

キーワード

• anxiety
• diazepam binding inhibitor
• nicotine dependence
• L-type high voltage-gated Ca²⁺ channel
• withdrawal syndrome

詳細情報

• CRID: 1390001205177513216
• NII論文ID: 10025726667
• NII論文ID: 130000073999
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.fmj04007x3
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 7289032
• PubMed: 15764844
• Web Site: http://id.ndl.go.jp/bib/7289032
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7289032
• Web Site: https://search.jamas.or.jp/link/ui/2006277642
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可