Inhibitory Mechanism of Papaverine on Carbachol-Induced Contraction in Bovine Trachea
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- Kaneda Takeharu
- Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University
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- Takeuchi Yukako
- Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University
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- Matsui Hirozumi
- Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University
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- Shimizu Kazumasa
- Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University
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- Urakawa Norimoto
- Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University
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- Nakajyo Shinjiro
- Division of Veterinary Pharmacology, Nippon Veterinary and Animal Science University
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We have demonstrated that the relaxing mechanism of papaverine in phasic muscles such as ileum, urinary bladder, and uterus is different from tonic muscles such as aorta. In this study, we examined the inhibitory mechanism of papaverine on carbachol (CCh)-induced contraction in the bovine trachea. Papaverine inhibited muscle contraction and increase in [Ca2+]i level induced by CCh. Papaverine increased cAMP content but not cGMP content. Papaverine did not affect CCh-induced oxidized flavoproteins fluorescence or reduced pyridine nucleotides fluorescence. Papaverine (30 μM) remarkably inhibited muscle tension, but slightly decreased creatine phosphate and ATP contents. Iberiotoxin restored the inhibitions of muscle contraction and [Ca2+]i level induced by papaverine or dibutyryl-cAMP. These results suggested that the relaxing mechanism of papaverine in the bovine trachea is mainly due to increases of cAMP content by inhibiting phosphodiesterase and the mechanism is partially involved in the activation of BK channel by cAMP.<br>
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 98 (3), 275-282, 2005
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205177014784
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- NII論文ID
- 10025728989
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 7368913
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- PubMed
- 15988126
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可