A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel

Access this Article

Author(s)

    • SASANO Tetsuo
    • Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
    • SUZUKI Takeshi
    • Division of Basic Biological Sciences, Faculty of Pharmacy, Keio University
    • KUROKAWA Junko
    • Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University
    • FURUKAWA Tetsushi
    • Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University

Abstract

We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K<sup>+</sup> currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogens have the same effect as that of 17β-estradiol, we investigated receptor-independent effects of estrone, estrone 3-sulfate, and estriol on hERG currents in patch-clamped estrogen-negative HEK293 cells. Only estrone 3-sulfate partially suppressed hERG currents in a receptor-independent manner by modifying the gating. The concentration-dependence of estrone 3-sulfate revealed that physiological levels of circulating estrone 3-sulfate can modulate hERG currents to the maximal extent in both women and men at any age.<br>

Journal

  • Journal of Pharmacological Sciences

    Journal of Pharmacological Sciences 109(1), 152-156, 2009-01-20

    The Japanese Pharmacological Society

References:  15

Cited by:  3

Codes

  • NII Article ID (NAID)
    10025734033
  • NII NACSIS-CAT ID (NCID)
    AA11806667
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13478613
  • NDL Article ID
    9773254
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top