Amelioration of Renal Ischemia-Reperfusion Injury by Inhibition of IL-6 Production in the Poloxamer 407-Induced Mouse Model of Hyperlipidemia

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  • Sharyo Satoru
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan Medicinal Safety Research Laboratories, R&D Division, Daiichi-Sankyo Co., Ltd., Japan
  • Kumagai Kazuyoshi
    Medicinal Safety Research Laboratories, R&D Division, Daiichi-Sankyo Co., Ltd., Japan
  • Yokota-Ikeda Naoko
    Nephrology Division, Miyazaki Prefectural Miyazaki Hospital, Japan
  • Ito Katsuaki
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan
  • Ikeda Masahiro
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Japan

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Abstract

It is largely unknown whether hyperlipidemia is involved in the pathobiology of renal ischemia–reperfusion (I/R) injury that is an important cause of acute kidney injury. Here we studied the effect of experimental dyslipidemia on renal I/R injury. Renal I/R injury was less severe in hyperlipidemic mice treated with poloxamer 407 than in the control mice. Cytokine analyses revealed decreased levels of renal and serum IL-6 in the hyperlipidemic mice after renal I/R. Protection from renal I/R injury in the hyperlipidemic mice was diminished by administration of recombinant IL-6. Concanavalin A–induced IL-6 release from cultured splenocytes derived from the hyperlipidemic mice was lower than that from splenocytes of normal mice. In hypercholesterolemic apolipoprotein E–knockout mice, in which renal I/R injury is less severe than in control mice, renal I/R–induced IL-6 production was also less than that in controls. In angiopoietin-like 3–deficient mice, which were hypolipidemic, renal dysfunction and renal IL-6 level after I/R were similar to those of control mice. Our data indicate that the presence of experimental hyperlipidemia may be associated with a decreased risk of renal I/R injury, possibly mediated by reduced renal IL-6 production after the insult and extend the notion that an anti-IL6 agent would be useful for the treatment of acute kidney injury.<br>

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