Clinical Significance of C-Reactive Protein among Japanese for Predicting Atherosclerotic Events

DOI Web Site 参考文献4件

この論文をさがす

抄録

There is growing evidence that local and systemic inflammation plays a role in the initiation and progression of atherosclerosis. Patients with acute coronary syndrome have increased CRP levels before onset.<br>However, the significance of CRP measurement has not been confirmed in healthy Japanese subjects and patients with atherosclerotic diseases.<br>Since 2000, we have started to measure hs-CRP using BN-II (Dade-Behring Co., IL, USA) in more than 3000 subjects annually.<br>The upper-limit of the normal range of hs-CRP is 1.0 mg/l in Japanese. Careful consideration is required in interpreting hs-CRP values. Aging, obesity, and smoking increase the values, while weight reduction, and a moderate intake of alcohol reduce the values.<br>The accumulation of numbers with regard to each component of metabolic syndrome indicates the elevation of hs-CRP in a stepwise manner. Patients with arrhythmia such as atrial fibrillation show elevated values.<br>A prospective study on Japanese in the Tokyo area indicated a 22% increase in cardiovascular events in high hs-CRP subjects compared to normal hs-CRP groups. The usefulness of the determination of hs-CRP with plasma lipids is confirmed when predicting high-risk subjects.

収録刊行物

参考文献 (4)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ