Relationship of Urinary cGMP Excretion with Aging and Menopausal Status in a General Population

• Cui Renzhe

  Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine

• Iso Hiroyasu

  Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine

• Yamagishi Kazumasa

  Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences and Institute of Community Medicine, University of Tsukuba

• Ohira Tetsuya

  Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine The Osaka Medical Center for Health Science and Promotion

• Tanigawa Takeshi

  Department of Public Health, Doctoral Program in Social Medicine, Graduate School of Medicine, Ehime University

• Kitamura Akihiko

  The Osaka Medical Center for Health Science and Promotion

• Kiyama Masahiko

  The Osaka Medical Center for Health Science and Promotion

• Imano Hironori

  Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine The Osaka Medical Center for Health Science and Promotion

• Konishi Masamitsu

  The Osaka Medical Center for Health Science and Promotion

• Shimamoto Takashi

  The Osaka Medical Center for Health Science and Promotion

抄録

Aim: Aging and postmenopausal women are associated with increased risks of cardiovascular disease; however, epidemiological evidence concerning the relationship of aging and the menopause with vascular biological activity is limited.<BR>Methods: We investigated the relationship of aging and the menopause with urinary excretion of cyclic guanosine 3',5' monophosphate (cGMP) in 1,541 Japanese men and women aged 40 to 79 years. The 24-hour urinary excretion of cGMP was measured with a ¹²⁵I-labeled cGMP radioimmunoassay and was adjusted for urinary creatinine excretion (nmol/mmol creatinine).<BR>Results: Aging was positively associated with urinary excretion of cGMP for both sexes. Postmenopausal women excreted significantly less urinary cGMP than premenopausal women after adjustment for age and other cardiovascular risk factors: 48.3±0.04 nmol/mmol vs. 61.5±0.07 nmol/mmol, p=0.006.<BR>Conclusions: Our data suggest that cGMP-related vasodilatation is impaired in postmenopausal women.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 16 (4), 457-462, 2009

  一般社団法人 日本動脈硬化学会

キーワード

• cGMP
• Postmenopausal
• Cross-sectional studies
• Epidemiology

詳細情報

• CRID: 1390282679408640384
• NII論文ID: 10025766604
• NII論文ID: 130004444306
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.no083
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://search.jamas.or.jp/link/ui/2010097294
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可