The hOGG1 Ser326Cys Polymorphism Is Not Associated with Colorectal Cancer Risk

DOI Web Site 被引用文献2件 参考文献38件
  • Park Hye-Won
    Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.
  • Kim Il-Jin
    Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.
  • Kang Hio Chung
    Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University. Research Institute and Hospital, National Cancer Center.
  • Jang Sang-Geun
    Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University. Research Institute and Hospital, National Cancer Center.
  • Ahn Sun-A
    Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University. Research Institute and Hospital, National Cancer Center.
  • Lee Jin Soo
    Research Institute and Hospital, National Cancer Center.
  • Shin Hai-Rim
    Research Institute and Hospital, National Cancer Center.
  • Park Jae-Gahb
    Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University.

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BACKGROUND: Little is known about the genetic risk factors associated with colorectal cancer. Although the Ser326Cys polymorphism of 8-oxoguanine DNA glycosylase (hOGG1) is consistently associated with a range of cancers, there is no consensus regarding this polymorphism and colorectal cancer risk.<br>METHODS: In the present study, conducted in a Korean population, we used the TaqMan assay to investigate whether the hOGG1 Ser326Cys polymorphism was associated with colorectal cancer in 439 colorectal cancer patients and 676 healthy normal controls. We also examined whether the hOGG1 Ser326Cys polymorphism is associated with tumor location, microsatellite instability (MSI) status and tumor-node-metastasis (TNM) stage in colorectal cancer.<br>RESULTS: We found no significant difference between the cancer and control populations in terms of genotype distribution (CC, CG and GG). In addition, we found no association between the hOGG1 Ser326Cys polymorphism and cancer risk, MSI status, TNM stage or tumor location in colorectal cancer patients.<br>CONCLUSIONS: These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer.<br>J Epidemiol 2007; 17: 156-160.

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