Association of Lipoprotein-associated Phospholipase A2 with Coronary Calcification among American and Japanese Men

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Author(s)

    • EL-SAED Aiman
    • Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh
    • SEKIKAWA Akira
    • Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh
    • ZAKY Riad Wahid
    • Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh
    • TAKAMIYA Tomoko
    • Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh
    • EDMUNDOWICZ Daniel
    • Preventive Cardiology, Cardiovascular Institute, University of Pittsburgh Medical Center Health Plan
    • KITA Yoshikuni
    • Department of Health Science, Shiga University of Medical Science
    • KULLER Lewis H.
    • Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh

Abstract

<b>BACKGROUND:</b> We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations.<br><b>METHODS:</b> A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002.<br><b>RESULTS:</b> Lp-PLA2 levels were higher among American than Japanese men (Mean ± standard deviation 301.7 ± 82.6 versus 275.9 ± 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol ≥130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels.<br><b>CONCLUSION:</b> Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.<br><i>J Epidemiol</i> 2007; 17: 179-185.

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 17(6), 179-185, 2007-11-01

    Japan Epidemiological Association

References:  23

Cited by:  1

Codes

  • NII Article ID (NAID)
    10025811498
  • NII NACSIS-CAT ID (NCID)
    AA10952696
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09175040
  • Data Source
    CJP  CJPref  J-STAGE 
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