耳科手術における周術期レボフロキサシン経口投与の有用性と適応の検討

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  • The usefulness of perioperative orally levofloxacin administration during otological surgery

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During otological surgery, levofloxacin was administered orally as a perioperative antimicrobial drug. The mean age of the subjects was 42.1 years old and the patients with chronic otitis media comprised 44%, followed by those with otitis media cholesteatoma of 33%. Other diseases included otoschlerosis, middle ear malformation, external acoustic meatus, ear canal tumor and middle ear tumor. Consequently, only 2 of 80 patients postoperatively prolonged purulent otorrhea exhibited, which was a successful outcome. However, considering the risk of the emergence of resistant strains, this method should not be applied to stapes surgery, which could be a clean surgery. The patient who exhibited prolonged purulent otorrhea postoperatively was one of the patients with otitis media cholesteatoma and had already developed purulent otorrhea prior to the operation. The mastoid cavity was filled up with bone pate after mastoidectomy. The surgery associated insertion of bone pate is beyond the application of this method. Therefore, patients who undergo this surgery should be fully protected from infection by intravenous administration of antimicrobial drugs and localized treatment.

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