Effects of Local and Whole Body Irradiation on the Appearance of Osteoblasts During Wound Healing in Tooth Extraction Sockets in Rats
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- HOSOKAWA Yoichiro
- Department of Radiological Life Sciences, Division of Medical Life sciences, Hirosaki University
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- SAKAKURA Yasunori
- Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido
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- IRIE Kazuharu
- Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido
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- KUDO Kohsei
- Department of Radiological Life Sciences, Division of Medical Life sciences, Hirosaki University
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- KASHIWAKURA Ikuo
- Department of Radiological Life Sciences, Division of Medical Life sciences, Hirosaki University
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Abstract
Irradiation before tooth extraction delays wound healing in the alveolar socket. This study examined the influences of local and whole body irradiation before tooth extraction on appearance of osteoblasts in the alveolar bone of rat maxillary first molars because bone formation is observed at the initial phase of wound healing. Several osteoblasts were generated 3 days after tooth extraction, and the number of cells increased day by day. Morphological studies showed there were little differences between local irradiation and non-irradiated controls. In contrast, the extraction wound in the whole body irradiation group showed delayed healing, and there was poor granulation tissue and very few osteoblasts at the bottom of the socket. An ultrastructural study showed that the osteoblasts in the extraction socket of whole body irradiation rats were smaller, and had poorly developed organelles. Injection of bone marrow cells to whole body-irradiated animals immediately after tooth extraction partially restored the number of osteoblasts. New periosteal bone formations outside of sockets showed little delay in the whole body irradiation group. These findings suggest that bone formation in the wound healing of extraction socket requires bone marrow cells from hematopoietic organs such as the bone marrow as well as local sources around the alveolar socket, during the initial phase of wound healing.
Journal
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- Journal of Radiation Research
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Journal of Radiation Research 51 (2), 181-186, 2010
Journal of Radiation Research Editorial Committee
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Details 詳細情報について
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- CRID
- 1390001205215751168
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- NII Article ID
- 10025914715
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- NII Book ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL BIB ID
- 10611763
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed