Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents

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  • MATSUURA Ayumu
    Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
  • KUBO Takayasu
    Clinic of Oral Implants, Hiroshima University Hospital
  • DOI Kazuya
    Clinic of Oral Implants, Hiroshima University Hospital
  • HAYASHI Kazuhiko
    Clinic of Oral Implants, Hiroshima University Hospital
  • MORITA Kouji
    Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
  • YOKOTA Rie
    Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
  • HAYASHI Hidetaka
    Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
  • HIRATA Isao
    Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
  • OKAZAKI Masayuki
    Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
  • AKAGAWA Yasumasa
    Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University

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Abstract

Hydroxyapatite and carbonate apatites with different carbonate contents were synthesized, mixed with atelocollagen, and made into sponge scaffolds. The scaffolds were implanted into the bone sockets of the femurs of male New Zealand white rabbits for 2, 3, 12 and 24 weeks. carbonate apatite-collagen scaffold with 4.8 wt% carbonate content appeared to have similar crystallinity and chemical composition to human bone. When the scaffolds were implanted into the rabbit femurs, histological observation indicated that the carbonate apatites-collagen scaffolds with relatively higher carbonate contents were gradually deformed throughout the implantation period, and showed uniform surrounding bone after 24 weeks and could not be distinguished. The carbonate apatite-collagen scaffold with 4.8 wt% carbonate content showed the highest bone area ratio of all of the scaffolds. It is suggested that a carbonate apatite-collagen scaffold with carbonate content similar to that of human bone may have optimal bone formation ability.

Journal

  • Dental Materials Journal

    Dental Materials Journal 28 (2), 234-242, 2009

    The Japanese Society for Dental Materials and Devices

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