Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents
-
- MATSUURA Ayumu
- Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
-
- KUBO Takayasu
- Clinic of Oral Implants, Hiroshima University Hospital
-
- DOI Kazuya
- Clinic of Oral Implants, Hiroshima University Hospital
-
- HAYASHI Kazuhiko
- Clinic of Oral Implants, Hiroshima University Hospital
-
- MORITA Kouji
- Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
-
- YOKOTA Rie
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- HAYASHI Hidetaka
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- HIRATA Isao
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- OKAZAKI Masayuki
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- AKAGAWA Yasumasa
- Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
Access this Article
Search this Article
Author(s)
-
- MATSUURA Ayumu
- Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
-
- KUBO Takayasu
- Clinic of Oral Implants, Hiroshima University Hospital
-
- DOI Kazuya
- Clinic of Oral Implants, Hiroshima University Hospital
-
- HAYASHI Kazuhiko
- Clinic of Oral Implants, Hiroshima University Hospital
-
- MORITA Kouji
- Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
-
- YOKOTA Rie
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- HAYASHI Hidetaka
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- HIRATA Isao
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- OKAZAKI Masayuki
- Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
- AKAGAWA Yasumasa
- Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
Abstract
Hydroxyapatite and carbonate apatites with different carbonate contents were synthesized, mixed with atelocollagen, and made into sponge scaffolds. The scaffolds were implanted into the bone sockets of the femurs of male New Zealand white rabbits for 2, 3, 12 and 24 weeks. carbonate apatite-collagen scaffold with 4.8 wt% carbonate content appeared to have similar crystallinity and chemical composition to human bone. When the scaffolds were implanted into the rabbit femurs, histological observation indicated that the carbonate apatites-collagen scaffolds with relatively higher carbonate contents were gradually deformed throughout the implantation period, and showed uniform surrounding bone after 24 weeks and could not be distinguished. The carbonate apatite-collagen scaffold with 4.8 wt% carbonate content showed the highest bone area ratio of all of the scaffolds. It is suggested that a carbonate apatite-collagen scaffold with carbonate content similar to that of human bone may have optimal bone formation ability.
Journal
-
- Dental Materials Journal
-
Dental Materials Journal 28(2), 234-242, 2009-03-01
The Japanese Society for Dental Materials and Devices
References: 19
-
1
- Bone remodeling and repair (News)-Tissue engineerings build new bone
-
SERVICE RF.
Science 289, 1498-1500, 2000
Cited by (1)
-
2
- <no title>
-
LINKOW LI
Theories and Techniques of Oral Implantology, 1970
Cited by (1)
-
3
- Bioceramic implant in surgically produced infrabony defects
-
NERY EB
J Periodontol 46, 328-347, 1975
Cited by (1)
-
4
- A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillaofacial surgery
-
IGNATIUS AA
J Biomed Mater Res 58, 564-569, 2001
Cited by (1)
-
5
- The formation of hydroxyapatite-gelatin composites at 38 ℃
-
TEN HUISEN KS
J Biomed Mater Res 28, 27-33, 1994
Cited by (1)
-
6
- Synthesis of functionally graded MgCO_3Apatite accelerating osteoblast adhesion
-
YAMASAKI Y
J Biomed Mater Res 62, 99-105, 2002
Cited by (1)
-
7
- A new calcium phosphate, Water-setting cement
-
BROWN WE
Cements Research Progress, 352-379, 1986
Cited by (1)
-
8
- Setting reactions and compressive strengths of calcium phosphate cements
-
FUKASE Y
J Dent Res 69, 1852-1856, 1990
Cited by (1)
-
9
- Stem cell technology and bioceramics : from cell to gene engineering
-
OHGUSHI H
J Biomed Mater Res (Apl Biomater) 48, 913-927, 1999
Cited by (1)
-
10
- The nature of bone carbonate
-
BILTZ RM
Clin Orthop 129, 279-292, 1977
Cited by (1)
-
11
- Solubility behavior of CO_3Apatites in relation to crystallinity
-
OKAZAKI M
Caries Res 15, 477-483, 1981
Cited by (1)
-
12
- Apatite crystallites : Effects of carbonate on morphology
-
LEGEROS RZ.
Science 155, 1409-1411, 1967
Cited by (1)
-
13
- <no title>
-
TANAHASHI M.
Biomaterials 17, 47-51, 1996
Cited by (10)
-
14
- Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings
-
ZHENG X.
Biomaterials 21, 841-849, 2000
DOI Cited by (9)
-
15
- Insolubilized properties of UV-irradiated CO_3apatite-collagen composites
-
OKAZAKI M.
Biomaterials 11, 568-572, 1990
Cited by (17)
-
16
- Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing
-
GBURECK U
Adv Func Mater 17, 3940-3945, 2007
Cited by (1)
-
17
- Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts
-
SILVER I. A.
Exp. Cell Res. 175, 266-276, 1988
Cited by (21)
-
18
- Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography
-
Itoh Manabu , Shimazu Atsushi , Hirata Isao , Yoshida Yasuhiro , Shintani Hideaki , Okazaki Masayuki
Biomaterials 25(13), 2577-2583, 2004-06
IR Cited by (5)
-
19
- Detailed Consideration of Physicochemical Properties of CO_3apatites as Biomaterials in Relation to Carbonate Content Using ICP, X-ray Diffraction, FT-IR, SEM, and HR-TEM
-
YOKOTA Rie , HAYASHI Hidetaka , HIRATA Isao , MIAKE Yasuo , YANAGISAWA Takaaki , OKAZAKI Masayuki
Dental Materials Journal 25(3), 597-603, 2006-09-01
J-STAGE NDL Digital Collections Ichushi Web References (25) Cited by (7)
Cited by: 5
-
1
- Creation of highly functional CO_3Ap-collagen scaffold biomaterials
-
OKAZAKI Masayuki
Dental Materials Journal 29(1), 1-8, 2010-01-01
IR J-STAGE Ichushi Web References (31) Cited by (4)
-
2
- Effect of calcium carbonate on bone formation on 4-META/MMA-TBB resin [in Japanese]
-
HENMI Masaru , SUGAYA Tsutomu , NAKATSUKA Megumi , KAWANAMI Masamitsu
北海道歯学雑誌 32(2), 114-123, 2012-03-15
IR Ichushi Web References (30)
-
3
- New development of carbonate apatite-chitosan scaffold based on lyophilization technique for bone tissue engineering
-
DWI ARIANI Maretaningtias , MATSUURA Ayumu , HIRATA Isao , KUBO Takayasu , KATO Koichi , AKAGAWA Yasumasa
Dental Materials Journal 32(2), 317-325, 2013-04-01
J-STAGE Ichushi Web References (49)
-
4
- Octacalcium phosphate (OCP)-based bone substitute materials
-
Suzuki Osamu
The Japanese dental science review 49(1), 58-71, 2013-05-01
Ichushi Web References (135)
-
5
- A novel glass ionomer cement containing MgCO_3 apatite induced the increased proliferation and differentiation of human pulp cells in vitro
-
LAITEERAPONG Arunee , LOCHAIWATANA Yossakit , HIRATA Isao , OKAZAKI Masayuki , MORI Kenta , MURAKAMI Shinya , POOLTHONG Suchit
Dental Materials Journal 31(5), 772-778, 2012-09-01
J-STAGE Ichushi Web References (23)