Effects of added mannitol on the setting reaction and mechanical strength of apatite cement

DOI Web Site 参考文献48件
  • SHIMOGORYO Ryoji
    Japan Institute for Advanced Dentistry Department of Biomaterials, Faculty of Dental Science, Kyushu University
  • EGURO Toru
    Japan Institute for Advanced Dentistry
  • KIMURA Eiichiro
    Japan Institute for Advanced Dentistry
  • MARUTA Michito
    Department of Biomaterials, Faculty of Dental Science, Kyushu University
  • MATSUYA Shigeki
    Department of Biomaterials, Faculty of Dental Science, Kyushu University Section of Bioengineering, Department of Dental Engineering, Fukuoka Dental College
  • ISHIKAWA Kunio
    Department of Biomaterials, Faculty of Dental Science, Kyushu University

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Apatite cement containing porogen can be a useful material for the fabrication of biporous (macro- and microporous) apatite, which has gained much attention as a bone substitute material because of its large surface area and that it improves cell penetration. In the present study, the effects of added mannitol on the setting reaction and mechanical strength of apatite cement were evaluated. Apatite cements containing 0–40 wt% of mannitol were prepared and allowed to set in 0.9% saline kept at 37°C for 1–7 days. Although the diametral tensile strength (DTS) value increased with time, it decreased with the amount of added mannitol. SEM observation and XRD analysis revealed that mannitol had no inhibitory effect on the transformation reaction of apatite cement to apatite. It was thus concluded that mannitol was a good candidate for the fabrication of biporous apatite because it is biocompatible, exhibits satisfactory dissolution behavior, and that it caused no inhibitory effects on the compositional transformation to apatitic material.

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