Immunohistochemistry of the Periodontal Ligament Fibroblasts in Orthodontic Tension Sides

• Watanabe Takehiro

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine Department of Orthodontics, Matsumoto Dental University Hospital

• Nakano Keisuke

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine Matsumoto Dental University Institute for Oral Science

• Shimizu Takako

  Department of Dental Diagnostic Sciences, Matsumoto Dental University Hospital

• Okafuji Norimasa

  Clinical Evaluation Unit, Matsumoto Dental University Graduate School of Oral Medicine

• Kurihara Saburo

  Matsumoto Dental University Institute for Oral Science

• Yamada Kazuhiro

  Clinical Evaluation Unit, Matsumoto Dental University Graduate School of Oral Medicine Department of Orthodontics, Matsumoto Dental University Hospital

• Kawakami Toshiyuki

  Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine Matsumoto Dental University Institute for Oral Science

Bibliographic Information

Other Title

• 歯科矯正学的牽引側における歯根膜線維芽細胞の免疫組織化学
• シカ キョウセイガクテキ ケンインガワ ニ オケル シコン マク センイ ガ サイボウ ノ メンエキ ソシキ カガク

Abstract

To establish an immunohistochemical basis for orthodontic treatment, we review early histopathological changes and immunohistochemical changes of Runx2 and Msx2 in vivo study using mouse periodontal ligament exposed to mechanical stress. Strong expressions of Runx2 and Msx2 were seen in periodontal fibroblasts of the tension side at 20 minutes after mechanical stress. Expressions of Runx2 and Msx2 became stronger in parallel with time, and at 24 hours after mechanical stress, the periodontal fibroblasts, cementoblasts, and osteoblasts showed strong expression. Moreover, ALP has also demonstrated similar strong expression. All these results strongly suggested that Runx2 promoted differentiation of osteoblasts at an early stage and Msx2 worked as an activator of Runx2 function.

Journal

• Journal of Hard Tissue Biology

  Journal of Hard Tissue Biology 18 (4), 175-180, 2009

  THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY

Keywords

• Orthodontic force
• Mechanical stress
• Periodontal ligament fibroblasts
• Runx2
• Msx2
• Immunohistochemistry

Details

• CRID: 1390001204458984192
• NII Article ID: 10025928030
• NII Article ID: 130004480482
• NII Book ID: AA11074332
• DOI: 10.2485/jhtb.18.175
• ISSN: 1880828X
• ISSN: 13417649
• NDL BIB ID: 10598137
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10598137
• Web Site: https://search.jamas.or.jp/link/ui/2010180586
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed