Servo-Controlled Hind-Limb Electrical Stimulation for Short-Term Arterial Pressure Control
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- Kawada Toru
- Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute
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- Shimizu Shuji
- Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute
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- Yamamoto Hiromi
- Division of Cardiology, Department of Internal Medicine, Kinki University School of Medicine
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- Shishido Toshiaki
- Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute
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- Kamiya Atsunori
- Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute
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- Miyamoto Tadayoshi
- Department of Physical Therapy, Faculty of Health Sciences, Morinomiya University of Medical Sciences
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- Sunagawa Kenji
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
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- Sugimachi Masaru
- Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute
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Abstract
Background: Autonomic neural intervention is a promising tool for modulating the circulatory system thereby treating some cardiovascular diseases. Methods and Results: In 8 pentobarbital-anesthetized cats, it was examined whether the arterial pressure (AP) could be controlled by acupuncture-like hind-limb electrical stimulation (HES). With a 0.5-ms pulse width, HES monotonically reduced AP as the stimulus current increased from 1 to 5 mA, suggesting that the stimulus current could be a primary control variable. In contrast, the depressor effect of HES showed a nadir approximately 10 Hz in the frequency range between 1 and 100 Hz. Dynamic characteristics of the AP response to HES approximated a second-order low-pass filter with dead time (gain: -10.2 ±1.6 mmHg/mA, natural frequency: 0.040 ±0.004 Hz, damping ratio 1.80 ±0.24, dead time: 1.38 ±0.13 s, mean ± SE). Based on these dynamic characteristics, a servo-controlled HES system was developed. When a target AP value was set at 20 mmHg below the baseline AP, the time required for the AP response to reach 90% of the target level was 38 ±10 s. The steady-state error between the measured and target AP values was 1.3 ±0.1 mmHg. Conclusions: Autonomic neural intervention by acupuncture-like HES might provide an additional modality to quantitatively control the circulatory system. (Circ J 2009; 73: 851 - 859)<br>
Journal
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- Circulation Journal
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Circulation Journal 73 (5), 851-859, 2009
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390001205104712832
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- NII Article ID
- 10025930175
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed