Differentiation Capacity of Endothelial Progenitor Cells Correlates With Endothelial Function in Healthy Young Men

• Miura Manabu

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Numaguchi Yasushi

  Department of Medical Science of Proteases, Nagoya University School of Medicine

• Ishii Masakazu

  Department of Medical Science of Proteases, Nagoya University School of Medicine

• Kubota Ryuji

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Takeuchi Toyonari

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Imamura Akiko

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Murakami Ryuichiro

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Kondo Takahisa

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Okumura Kenji

  Department of Cardiovascular Research Medicine, Nagoya University School of Medicine

• Murohara Toyoaki

  Department of Cardiology, Nagoya University Graduate School of Medicine

抄録

Background: Endothelial progenitor cells (EPCs) have been assumed to maintain vascular endothelial integrity, so the present study investigated whether the functional capacity of EPCs correlates with endothelial function in healthy young subjects, as has been confirmed in aged subjects with atherosclerotic disease. Methods and Results: EPCs in 41 healthy, young male nonsmokers (age 33.1 ±3.9 years, mean ± SD) were characterized. The correlation between flow-mediated vasodilation (FMD) and the number of EPCs or the plasma concentrations of growth factors, such as vascular endothelial growth factor, did not reach statistical significance. However, FMD was significantly correlated with the EPC differentiation index, defined as the ratio of the number of EPCs to the total number of adherent cells (r=0.391, P=0.011) and the abundance of endothelial nitric oxide synthase mRNA (r=0.340, P=0.030). Conclusions: In healthy young men, despite a lack of correlation of the number or colony counts of EPCs, the ability of circulating progenitor cells to differentiate into an endothelial lineage is closely correlated with endothelial function. This cell function assay may serve as a novel biomarker for vascular function in healthy subjects in the pre-atherosclerotic stage. (Circ J 2009; 73: 1324-1329)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 73 (7), 1324-1329, 2009

  一般社団法人 日本循環器学会

キーワード

• Angiogenesis
• Atherosclerosis
• Endothelial function
• Endothelial progenitor cells

詳細情報

• CRID: 1390001205103558144
• NII論文ID: 10025932869
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-08-0952
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/73/7/73_CJ-08-0952/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009345458
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可