Two Patients With Bepridil-Induced Interstitial Pneumonia

• Watanabe Masataka

  Department of Cardiology, Tokyo Medical University

• Takata Yoshifumi

  Department of Cardiology, Tokyo Medical University

• Fukasawa Shinya

  Department of Cardiology, Tokyo Medical University

• Sakota Kunihiro

  Department of Cardiology, Tokyo Medical University

• Abe Tetsuya

  Department of Respiratory Medicine, Tokyo Medical University

• Goseki Yoshinari

  Department of Cardiology, Tokyo Medical University

• Setoguchi Yasuhiro

  Department of Respiratory Medicine, Tokyo Medical University

• Chikamori Taishiro

  Department of Cardiology, Tokyo Medical University

• Yamashina Akira

  Department of Cardiology, Tokyo Medical University

Abstract

Two patients developed bepridil-induced interstitial pneumonia during treatment of arrhythmia. The first patient was a 69-year-old man who received bepridil to maintain sinus rhythm in atrial fibrillation and who developed dyspnea on the 20^th day after administration. The second patient was a 72-year-old man who received bepridil for paroxysmal atrial fibrillation and who developed dyspnea on the 60^th day after administration. They were diagnosed with interstitial pneumonia on the basis of physical and imaging findings. The first patient was discharged after steroid pulse therapy, and the second patient after improvement of physical and imaging findings when bepridil was discontinued. Although a limited number of cases of bepridil-induced interstitial pneumonia have been reported, the disorder should be kept in mind as an important adverse reaction when breathlessness or dyspnea develops during administration of the drug. (Circ J 2009; 73: 1352-1355)<br>

Journal

• Circulation Journal

  Circulation Journal 73 (7), 1352-1355, 2009

  The Japanese Circulation Society

Keywords

• Atrial fibrillation
• Bepridil
• Interstitial pneumonia

Details

• CRID: 1390282680080259200
• NII Article ID: 10025933003
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-08-0234
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/73/7/73_CJ-08-0234/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009345464
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed