High Ratio of Myeloid Dendritic Cells to Plasmacytoid Dendritic Cells in Blood of Patients With Acute Coronary Syndrome

• Fukunaga Takashi

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Soejima Hirofumi

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Irie Atsushi

  Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University

• Fukushima Ryuichiro

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Oe Yoko

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Kawano Hiroaki

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Sumida Hitoshi

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Kaikita Koichi

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Sugiyama Seigo

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

• Nishimura Yasuharu

  Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University

• Ogawa Hisao

  Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University

Abstract

Background: Dendritic cells (DCs) stimulate T-cells to participate in the inflammatory processes that promote the destruction of vulnerable plaques. The relationship between circulating levels of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in patients with acute coronary syndrome (ACS) was evaluated. Methods and Results: Blood samples were obtained from 39 patients with ACS, 41 patients with stable angina pectoris (SAP) and 43 controls. The proportion of mDCs tended to be lower in the ACS group than in the SAP group and controls. Interleukin-12 levels associated with mDCs were significantly higher in the ACS group than in control group. The proportion of pDCs was significantly lower in the ACS groups than in the other two groups. Interferon-α levels secreted by pDCs, however, were not significantly different among the 3 groups. The ratio of mDCs to pDCs ≥4 is an important value for distinguishing ACS from SAP patients and control patients through receiver operating characteristic analysis (sensitivity; 85.0%, specificity; 83.4%). Conclusions: The ratio of mDCs to pDCs may be a useful marker for detecting ACS and the existence of vulnerable plaques. (Circ J 2009; 73: 1914-1919)<br>

Journal

• Circulation Journal

  Circulation Journal 73 (10), 1914-1919, 2009

  The Japanese Circulation Society

Keywords

• Acute coronary syndrome
• Interferon-α
• Interleukin-12
• Myeloid dendritic cells
• Plasmacytoid dendritic cells

Details

• CRID: 1390282680079225472
• NII Article ID: 10025936326
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-08-1193
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/73/10/73_CJ-08-1193/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010070619
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed