LOX-1 The Multifunctional Receptor Underlying Cardiovascular Dysfunction

• Ogura Sayoko

  Department of Vascular Physiology, National Cardiovascular Center

• Kakino Akemi

  Department of Vascular Physiology, National Cardiovascular Center

• Sato Yuko

  Department of Vascular Physiology, National Cardiovascular Center

• Fujita Yoshiko

  Department of Vascular Physiology, National Cardiovascular Center

• Iwamoto Shin

  Department of Vascular Physiology, National Cardiovascular Center

• Otsui Kazunori

  Department of Vascular Physiology, National Cardiovascular Center

• Yoshimoto Ryo

  Department of Vascular Physiology, National Cardiovascular Center

• Sawamura Tatsuya

  Department of Vascular Physiology, National Cardiovascular Center

Bibliographic Information

Other Title

• The Multifunctional Receptor Underlying Cardiovascular Dysfunction

Abstract

Oxidatively modified low-density lipoprotein (oxLDL) is implicated in the pathogenesis of atherosclerosis. Endothelial dysfunction is the initial change in the vascular wall that induces morphological changes for atheroma-formation. Lectin-like oxidized LDL receptor-1 (LOX-1) was identified as the receptor for oxLDL that was thought to be a major cause of endothelial dysfunction. LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but also to atherosclerotic-plaque formation, myocardial infarction and intimal thickening after balloon injury. Recent findings on the genetics of LOX-1 and the methodology to detect it and its ligands would further facilitate the examination of the receptor's pathophysiological contribution in atherosclerosis. Furthermore, LOX-1-related tools might open new gateways from diagnosis to therapeutics for cardiovascular diseases. (Circ J 2009; 73: 1993-1999)<br>

Journal

• Circulation Journal

  Circulation Journal 73 (11), 1993-1999, 2009

  The Japanese Circulation Society

Keywords

• Atherosclerosis
• Endothelial dysfunction
• LOX-1
• Oxidized low-density lipoprotein

Details

• CRID: 1390001205102420992
• NII Article ID: 10025936843
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-09-0587
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/73/11/73_CJ-09-0587/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010072502
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed