Blood Eicosapentaenoic Acid and Docosahexaenoic Acid as Predictors of All-Cause Mortality in Patients With Acute Myocardial Infarction Data From Infarction Prognosis Study (IPS) Registry

DOI Web Site PubMed 10 Citations 65 References
  • Lee Sang-Hak
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Shin Min-Jeong
    Department of Food and Nutrition, College of Health Science, Korea University
  • Kim Jung-Sun
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Ko Young-Guk
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Kang Seok-Min
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Choi Donghoon
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Jang Yangsoo
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Chung Namsik
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Shim Won-Heum
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Cho Seung-Yun
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine
  • Manabe Ichiro
    Department of Cardiovascular Medicine and Nano-Bioengineering Education Program, Graduate School of Medicine, The University of Tokyo
  • Ha Jong-Won
    Cardiology Division, Department of Internal Medicine, Yonsei University College of Medicine

Bibliographic Information

Other Title
  • Blood eicosapentaenoic acid and docosahexaenoic acid as predictors of all-cause mortality in patients with acute myocardial infarction—data from Infarction Prognosis Study (IPS) Registry
  • Data From Infarction Prognosis Study (IPS) Registry

Search this article

Abstract

Background: Although ω-3 polyunsaturated fatty acids are known to have beneficial effects on cardiovascular diseases, their prognostic value has not been studied prospectively in patients with acute myocardial infarction (AMI). Methods and Results: The plasma levels of phospholipids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (% of total fatty acids), were measured in 508 patients (365 males; mean age, 63 years) with AMI. Clinical and biomarker predictors of all-cause and cardiovascular mortality were identified by stepwise Cox regression model. During a mean follow-up of 16.1 months, 36 (7.1%) patients died. After controlling for confounding variables, age (hazard ratio (HR): 1.09, P<0.001), renal insufficiency (HR: 2.84, P=0.01) and EPA level (HR: 0.29, P=0.004) were identified as independent predictors of all cause-mortality. When stratified by gender, age (HR: 1.08, P=0.001) and renal insufficiency (HR: 4.49, P=0.003) were predictors of all-cause-mortality in males, whereas EPA level (HR: 0.18, P=0.009) and angiotensin-converting enzyme inhibitor use (HR: 0.24, P=0.03) were identified as predictive of all-cause-mortality in females. Conclusions: Lower plasma level of EPA, but not DHA, was an independent predictor for all-cause-mortality in patients with AMI, but this relationship was significant only in female patients. (Circ J 2009; 73: 2250-2257)<br>

Journal

  • Circulation Journal

    Circulation Journal 73 (12), 2250-2257, 2009

    The Japanese Circulation Society

Citations (10)*help

See more

References(65)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top