Tissue Factor and Cardiovascular Disease: Quo Vadis?

DOI Web Site 被引用文献8件 参考文献215件
  • Breitenstein Alexander
    Cardiovascular Research, Physiology Institute, University of Zurich Center for Integrative Human Physiology, University of Zurich Cardiology, Cardiovascular Center, University Hospital Zurich
  • Tanner Felix C.
    Cardiovascular Research, Physiology Institute, University of Zurich Center for Integrative Human Physiology, University of Zurich Cardiology, Cardiovascular Center, University Hospital Zurich
  • Lüscher Thomas F.
    Cardiovascular Research, Physiology Institute, University of Zurich Center for Integrative Human Physiology, University of Zurich Cardiology, Cardiovascular Center, University Hospital Zurich

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  • Quo Vadis?

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The coagulation cascade represents a system of proteases responsible to maintain vascular integrity and to induce rapid clot formation after vessel injury. Tissue factor (TF), the key initiator of the coagulation cascade, binds to factor VIIa and thereby activates factor IX and factor X, resulting in thrombus formation. Different stimuli enhance TF gene expression in endothelial and vascular smooth muscle cells. In addition to these vascular cells, TF has recently been detected in the bloodstream in circulating cells such as leukocytes and platelets, as a component of microparticles, and as a soluble, alternatively spliced form of TF. Various cardiovascular risk factors like hypertension, diabetes, and dyslipidemia, increase levels of TF. In line with this observation, enhanced vascular TF expression occurs during atherogenesis, particularly in patients with acute coronary syndromes. (Circ J 2010; 74: 3 - 12)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 74 (1), 3-12, 2010

    一般社団法人 日本循環器学会

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