Fasting Serum Level of Fatty-Acid-Binding Protein 4 Positively Correlates With Metabolic Syndrome in Patients With Coronary Artery Disease

• Hsu Bang-Gee

  School of Medicine, Tzu Chi University Division of Nephrology, Buddhist Tzu Chi General Hospital

• Chen Yu-Chih

  Division of Cardiology, Buddhist Tzu Chi General Hospital

• Lee Ru-Ping

  Department of Nursing, Tzu Chi University

• Lee Chia-Chi

  Department of Nursing, Tzu Chi College of Technology

• Lee Chung-Jen

  Department of Nursing, Tzu Chi College of Technology

• Wang Ji-Hung

  Division of Cardiology, Buddhist Tzu Chi General Hospital

抄録

Background: The serum level of fatty-acid-binding protein 4 (FABP4) increases in patients with metabolic syndrome (MetS), so the relationship between FABP4 and MetS among patients with coronary artery disease (CAD) was investigated in the present study. Methods and Results: Fasting blood samples were obtained from 98 CAD patients. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation; 50 CAD patients (51.0%) had MetS. The fasting level of FABP4 positively correlated with MetS (P=0.037) and serum levels of FABP4 correlated with a number of MetS criteria (P=0.035). Univariate linear regression analysis showed that body fat mass (R=0.234; P=0.020) and the levels of triglycerides (R=0.348; P<0.001), and low-density lipoprotein-cholesterol (R=0.217; P=0.032) positively correlated with the serum level of FABP4, whereas the level of high-density lipoprotein-cholesterol (R=-0.243; P=0.016) negatively correlated with it. Multivariate forward stepwise linear regression analysis of the significant variables showed that the level of triglycerides (β=0.348, R²=0.121, P<0.001) was the independent predictor of fasting serum level of FABP4. Conclusions: Among CAD patients in the present study, the fasting level of FABP4 positively correlated with MetS and serum levels of FABP4 correlated with a number of MetS criteria. (Circ J 2010; 74: 327-331)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 74 (2), 327-331, 2010

  一般社団法人 日本循環器学会

キーワード

• Coronary artery disease
• Fatty-acid-binding protein 4
• Metabolic syndrome

詳細情報

• CRID: 1390001205105533568
• NII論文ID: 10025942586
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-09-0568
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/74/2/74_CJ-09-0568/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010140285
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可