Genotoxicity Studies of Heavy Metals: Lead, Bismuth, Indium, Silver and Antimony

• Asakura Keiko

  Department of Preventive Medicine and Public Health, Keio University School of Medicine

• Satoh Hiroshi

  Environmental Health Sciences, Tohoku University Graduate School of Medicine

• Chiba Momoko

  School of Pharmaceutical Sciences, International University of Health and Welfare

• Okamoto Masahide

  Department of Packaging Technology Solutions, Production Engineering Research Laboratory, Hitachi Ltd.

• Serizawa Koji

  Department of Packaging Technology Solutions, Production Engineering Research Laboratory, Hitachi Ltd.

• Nakano Makiko

  Department of Preventive Medicine and Public Health, Keio University School of Medicine

• Omae Kazuyuki

  Department of Preventive Medicine and Public Health, Keio University School of Medicine

Abstract

Objectives: Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. Methods: Bacterial reverse mutation tests and chromosomal aberration tests in cultured mammalian cells were performed according to standard procedures. Results: Antimony showed genotoxicity in both tests, and bismuth also showed positive results in the chromosomal aberration test. In contrast, lead, indium, and silver were considered to be inactive by the criteria of the present study. Conclusions: Although further studies are needed because of the difficulty of genotoxicity evaluation using an in vitro system, sufficient precautions should be made when antimony and bismuth are used.<br>

Journal

• Journal of Occupational Health

  Journal of Occupational Health 51 (6), 498-512, 2009

  Japan Society for Occupational Health

Keywords

• Bacterial reverse mutation test
• Chromosomal aberration test in cultured mammalian cells
• Genotoxicity
• Heavy metals

Details

• CRID: 1390001204455236608
• NII Article ID: 10025966383
• NII Book ID: AA11090645
• DOI: 10.1539/joh.l9080
• ISSN: 13489585
• ISSN: 13419145
• NDL BIB ID: 10457293
• Web Site: http://id.ndl.go.jp/bib/10457293
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10457293
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1539%2Fjoh.L9080
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1539/joh.L9080
• Web Site: https://search.jamas.or.jp/link/ui/2010128552
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed