Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats

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Author(s)

    • Ikeda Ikuo IKEDA Ikuo
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • NAGAO Koji
    • Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University
    • OSHIRO Yoko
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • KATO Masaki
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • SUGAWARA Takashi
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • YAMAHIRA Takashi
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • ITO Hiroko
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • TAMARU Shogo
    • Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
    • SATO Masao
    • Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
    • IMAIZUMI Katsumi
    • Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
    • NAGAOKA Satoshi
    • Laboratory of Molecular Function of Food, Faculty of Applied Biological Sciences, Gifu University

Abstract

Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and HMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.

Journal

  • Journal of Nutritional Science and Vitaminology

    Journal of Nutritional Science and Vitaminology 55(3), 252-256, 2009-06-01

    Center for Academic Publications Japan

References:  23

Cited by:  2

Codes

  • NII Article ID (NAID)
    10025971374
  • NII NACSIS-CAT ID (NCID)
    AA00703822
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    03014800
  • NDL Article ID
    10251996
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B484
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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