Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats

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  • IKEDA Ikuo
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
  • KUDO Mariko
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
  • HAMADA Tadateru
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
  • NAGAO Koji
    Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University
  • OSHIRO Yoko
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
  • KATO Masaki
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
  • SUGAWARA Takashi
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
  • YAMAHIRA Takashi
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
  • ITO Hiroko
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
  • TAMARU Shogo
    Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University
  • SATO Masao
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
  • IMAIZUMI Katsumi
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Graduate School of Kyushu University
  • NAGAOKA Satoshi
    Laboratory of Molecular Function of Food, Faculty of Applied Biological Sciences, Gifu University
  • YANAGITA Teruyoshi
    Laboratory of Nutrition Biochemistry, Faculty of Agriculture, Saga University

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Abstract

Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS. Hepatic expression of ATP-binding cassette transporter G5 (ABCG5) and ATP-binding cassette transporter G8 (ABCG8) mRNA was significantly higher in rats fed SPI and HMF than in those fed CAS. These observations suggest that increased biliary excretion of cholesterol in SPI and HMF groups is caused by the enhanced expression of Abcg5/Abcg8.

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