The Soy Isoflavone Equol Enhances Antigen-Specific IgE Production in Ovalbumin-Immunized BALB/c Mice

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Author(s)

    • Sakai Tohru SAKAI Tohru
    • Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University of Tokushima
    • SHUTO Emi
    • Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University of Tokushima
    • HOSAKA Toshio
    • Department of Public Health and Applied Nutrition, Institute for Health Biosciences, The University of Tokushima
    • NISHIOKA Yasuhiko
    • Department of Respiratory Medicine and Rheumatology, Institute for Health Biosciences, The University of Tokushima
    • SONE Saburo
    • Department of Respiratory Medicine and Rheumatology, Institute for Health Biosciences, The University of Tokushima

Abstract

Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T cell and B cell responses in BALB/c mice. Mice that had been treated with 20 mg/kg equol showed a significantly higher level of OVA-specific IgE than control mice. Levels of interferon (IFN)-γ and interleukin (IL)-4 production were not different between the control and equol groups. However, IL-13 production level in mice administered 20 mg/kg equol was significantly higher than that in control mice. Strong induction of OVA-specific IgE production by equol was also observed in ovariectomized BALB/c mice, suggesting that the immunomodulatory effect of equol is not affected by endogenous estrogen.

Journal

  • Journal of Nutritional Science and Vitaminology

    Journal of Nutritional Science and Vitaminology 56(1), 72-76, 2010-02-01

    Center for Academic Publications Japan

References:  27

Codes

  • NII Article ID (NAID)
    10025973044
  • NII NACSIS-CAT ID (NCID)
    AA00703822
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    03014800
  • NDL Article ID
    10575724
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B484
  • Data Source
    CJP  NDL  J-STAGE 
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