Targeted deletion of matrix metalloproteinase-9 reduces neutrophil accumulation during G－CSF-induced neoangiogenesis

DOI 31 References
  • Sato Yayoi
    Laboratory of Stem Cell Regulation, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo Division of Cardiology, Department of Internal Medicine, Juntendo University School of medicine
  • Ohki Yuichi
    Laboratory of Stem Cell Regulation, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo Division of Cardiology, Department of Internal Medicine, Juntendo University School of medicine
  • Akiyama Haruyo
    Laboratory of Stem Cell Regulation, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo
  • Rosenkvist Jeanette
    Laboratory of Stem Cell Regulation, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo
  • Gritli Ismael
    Laboratory of Stem Cell Regulation, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo
  • Okumura Ko
    Atopy（Allergy）Research Center, Juntendo University School of Medicine
  • Ogawa Hideoki
    Atopy（Allergy）Research Center, Juntendo University School of Medicine
  • Daida Hiroyuki
    Division of Cardiology, Department of Internal Medicine, Juntendo University School of medicine
  • Heissig Beate
    Laboratory of Stem Cell Regulation, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo Atopy（Allergy）Research Center, Juntendo University School of Medicine Frontier Research Initiative, Institute of Medical Science at the University of Tokyo
  • Hattori Koichi
    Laboratory of Stem Cell Regulation, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo Atopy（Allergy）Research Center, Juntendo University School of Medicine
  • Ohsaka Akimichi
    Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine

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Other Title
  • 生体内マトリックスメタロプロテイナーゼー9の特異的活性抑制に伴う組織内好中球浸潤減少のG－CSF誘導血管新生における意義

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Abstract

<p>造血因子の一つである顆粒球コロニー刺激因子（G－CSF）は近年，生体中において血管新生誘導作用を有することが確認され，一部の血管閉塞性疾患に対し，臨床治験も進められている。本研究で，G－CSFによる骨髄由来のCD11b陽性Gr－1陽性細胞，好中球分画の末梢血，組織中への動員では，生体組織中のマトリックスメタロプロテイナーゼ－9（MMP－9）の活性化が重要であることが判明した。またG－CSF によるMMP－9の活性化に伴い，動員されたこれらの分画の細胞は，末梢に形成された虚血壊死組織に対し，血管内皮増殖因子VEGFの供給源として機能し，最終的に血管新生及び組織再生を誘導することが示唆された。</p>

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