内耳免疫現象によるめまい発症について

• 富山 俊一

書誌事項

タイトル別名

• Immunological Pathogenesis in Vertigo Attack

抄録

The hypothesis that certain types of vertigo develop through immunopathological mechanisms has been advocated for over 80 years. These days, many reports have been published that link immunity and vertigo with a variety of proposed immune-related etiologies, from autoimmunity to non-autoimmunity. Due to the inaccessibility of the labyrinth, it is difficult to take out obtain specimens of the inner ear tissue. In this paper, we present an animal model of Meniere's disease. Immune reaction following secondary antigen challenge in the endolymphatic sac of guinea pigs led to the development of endolymphatic hydrops, fluctuating hearing loss, precipitation of vertigo and suppression of the caloric response, similar to the symptomatology of Meniere's disease. These results strongly suggest that immune reaction in the endolymphatic sac is the likely cause of vertigo in Meniere's disesae. It is difficult to clinically distinguish between autoimmune inner ear disease and Meniere's disease, because of their clinical similarity. Western blotting examination of the serum for inner ear autoantibodies may aid in the differential diagnosis. Immunosuppressive drug treatment may be effective in patients with severe vertigo who show resistance to therapies used for Meniere's disease.

収録刊行物

• Ｅｑｕｉｌｉｂｒｉｕｍ　Ｒｅｓｅａｒｃｈ

  Ｅｑｕｉｌｉｂｒｉｕｍ　Ｒｅｓｅａｒｃｈ 67 (3), 242-250, 2008

  一般社団法人 日本めまい平衡医学会

キーワード

• inner ear immunology
• animal model study
• Meniere's disease
• autoantibody
• autoimmune inner ear disease

詳細情報

• CRID: 1390001204950124416
• NII論文ID: 10026087550
• NII書誌ID: AN00001485
• DOI: 10.3757/jser.67.242
• ISSN: 1882577X
• ISSN: 03855716
• Web Site: https://www.jstage.jst.go.jp/article/jser/67/3/67_3_242/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008260602
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可