Natural history of human T-lymphotropic virus type 1 infection and immune system imbalances

• Okayama Akihiko

  Department of Rheumatology, Infectious Diseases and Laboratory Medicine, Miyazaki, Japan

抄録

The human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition, increased incidences of infectious diseases, autoimmune diseases, chronic inflammatory diseases and virus-associated malignancies are observed in HTLV-1 carriers. HTLV-1 infection causes the continuous activation and clonal expansion of T cells. The levels of regulatory T cells and na?ve T-cells are decreased in the peripheral blood of asymptomatic carriers. Spontaneous proliferation of peripheral blood mononuclear cells and subclinical deficiencies in both type 1 and type 2 immunity are also observed. It is possible that the immune system imbalances seen in HTLV-1 infection account for the disease manifestations described above, although the precise mechanism remains unclear.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 30 (2), 103-108, 2010

  一般社団法人 日本炎症・再生医学会

キーワード

• HTLV-1 infection
• asymptomatic carriers
• mmune system imbalances

詳細情報

• CRID: 1390282680234182272
• NII論文ID: 130004482255
• NII論文ID: 10026094363
• NII書誌ID: AA11508953
• DOI: 10.2492/inflammregen.30.103
• ISSN: 18808190
• ISSN: 18809693
• NDL書誌ID: 10644804
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10644804
• Web Site: https://search.jamas.or.jp/link/ui/2010265249
• 本文言語コード: en
• データソース種別:
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  • NDL
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• 抄録ライセンスフラグ: 使用不可