ジベレリン受容体のジベレリン識別とエフェクター認識 [in Japanese] Gibberellin Perception by the Gibberellin Receptor and its Effector Recognition [in Japanese]
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Gibberellins control a diverse range of growth and developmental processes in higher plants and have been widely utilized in the agricultural industry. By binding to a nuclear receptor GIBBERELLIN INSENSITIVE DWARF1 (GID1), gibberellins regulate gene expression by promoting degradation of the transcriptional regulator DELLA proteins. The precise manner in which GID1 discriminates and becomes activated by bioactive gibberellins for specific binding to DELLA proteins remains unclear. We present the crystal structure of a ternary complex of <i>Arabidopsis thaliana</i> GID1A, a bioactive gibberellin and the N-terminal DELLA domain of GAI. In this complex, GID1a occludes gibberellin in a deep binding pocket covered by its N-terminal helical switch region, which in turn interacts with the DELLA domain containing DELLA, VHYNP and LExLE motifs. Our results establish a structural model of a plant hormone receptor which is distinct from the hormone-perception mechanism and effector recognition of the known auxin receptors.
- Nihon Kessho Gakkaishi
Nihon Kessho Gakkaishi 52(1), 37-41, 2010-02-28
The Crystallographic Society of Japan