ジベレリン受容体のジベレリン識別とエフェクター認識  [in Japanese] Gibberellin Perception by the Gibberellin Receptor and its Effector Recognition  [in Japanese]

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Author(s)

    • 箱嶋 敏雄 HAKOSHIMA Toshio
    • 奈良先端科学技術大学院大学情報科学研究科 Graduate School of Information Science, Nara Institute of Science and Technology
    • 村瀬 浩司 MURASE Kohji
    • 奈良先端科学技術大学院大学情報科学研究科 Graduate School of Information Science, Nara Institute of Science and Technology
    • 平野 良憲 HIRANO Yoshinori
    • 奈良先端科学技術大学院大学情報科学研究科 Graduate School of Information Science, Nara Institute of Science and Technology

Abstract

Gibberellins control a diverse range of growth and developmental processes in higher plants and have been widely utilized in the agricultural industry. By binding to a nuclear receptor GIBBERELLIN INSENSITIVE DWARF1 (GID1), gibberellins regulate gene expression by promoting degradation of the transcriptional regulator DELLA proteins. The precise manner in which GID1 discriminates and becomes activated by bioactive gibberellins for specific binding to DELLA proteins remains unclear. We present the crystal structure of a ternary complex of <i>Arabidopsis thaliana</i> GID1A, a bioactive gibberellin and the N-terminal DELLA domain of GAI. In this complex, GID1a occludes gibberellin in a deep binding pocket covered by its N-terminal helical switch region, which in turn interacts with the DELLA domain containing DELLA, VHYNP and LExLE motifs. Our results establish a structural model of a plant hormone receptor which is distinct from the hormone-perception mechanism and effector recognition of the known auxin receptors.

Journal

  • Nihon Kessho Gakkaishi

    Nihon Kessho Gakkaishi 52(1), 37-41, 2010-02-28

    The Crystallographic Society of Japan

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Codes

  • NII Article ID (NAID)
    10026107815
  • NII NACSIS-CAT ID (NCID)
    AN00188364
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    03694585
  • NDL Article ID
    10622846
  • NDL Source Classification
    ZM46(科学技術--地球科学--岩石・鉱物・鉱床)
  • NDL Call No.
    Z15-138
  • Data Source
    CJP  NDL  J-STAGE 
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